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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 11
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pubmed:dateCreated |
2008-11-10
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pubmed:abstractText |
Crystals of recombinant NovN, an O-carbamoyltransferase from Streptomyces spheroides, were grown by vapour diffusion. The protein crystallized in two different crystal forms. Crystal form I belonged to space group C2 and native data were collected to 2.9 A resolution in-house. Crystal form II had I-centred orthorhombic symmetry and native data were recorded to a resolution of 2.3 A at a synchrotron. NovN catalyses the final step in the biosynthesis of the aminocoumarin antibiotic novobiocin that targets the essential bacterial enzyme DNA gyrase.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-11092928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-11419950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-12570764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-14694473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-15157876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-16369093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-16369096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-16569821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-16868863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-3537305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-5700707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-6295263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-8635474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-9080608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18997325-9245398
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1744-3091
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1000-2
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides.
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pubmed:affiliation |
Department of Biological Chemistry, John Innes Centre, Norwich NR4 7UH, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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