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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-19
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pubmed:abstractText |
We have previously shown that mice heterozygously deficient for P0 are characterized by a late onset myelin disorder implicating CD8+ T-lymphocytes and macrophages. We now investigated the impact of the co-inhibitory molecule "programmed death" (PD)-1 (CD279), a CD28-related receptor expressed on activated T- and B-lymphocytes on the pathogenic phenotype of CD8+ T-lymphocytes in the P0 myelin mutants. PD-1 deficiency in P0+/- mice leads to a stronger increase of CD8+ T-lymphocytes and a substantially aggravated histological phenotype in the PNS compared to P0+/- mice expressing PD-1. Correspondingly, functional down-stream features, such as electrophysiological parameters, walking coordination and mechano-sensation are more affected than in PD-1-expressing myelin mutants. Our study demonstrates that a monogenic nerve disorder can be substantially modified by immune-controlling mechanisms. Thus, understanding the implication of disease-modifiers in inherited demyelination could be of pivotal interest for limiting the detrimental impact of primarily genetically-mediated myelin disorders by fostering immuno-regulatory pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1095-953X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-103
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18996482-Animals,
pubmed-meshheading:18996482-Antigens, Surface,
pubmed-meshheading:18996482-Apoptosis Regulatory Proteins,
pubmed-meshheading:18996482-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18996482-Charcot-Marie-Tooth Disease,
pubmed-meshheading:18996482-Chimera,
pubmed-meshheading:18996482-Demyelinating Diseases,
pubmed-meshheading:18996482-Disease Models, Animal,
pubmed-meshheading:18996482-Flow Cytometry,
pubmed-meshheading:18996482-Gait Apraxia,
pubmed-meshheading:18996482-Interferon-gamma,
pubmed-meshheading:18996482-Lymphocyte Activation,
pubmed-meshheading:18996482-Macrophages,
pubmed-meshheading:18996482-Mice,
pubmed-meshheading:18996482-Mice, Inbred C57BL,
pubmed-meshheading:18996482-Mice, Transgenic,
pubmed-meshheading:18996482-Peripheral Nervous System Diseases,
pubmed-meshheading:18996482-Programmed Cell Death 1 Receptor,
pubmed-meshheading:18996482-Quadriceps Muscle,
pubmed-meshheading:18996482-Sciatic Nerve,
pubmed-meshheading:18996482-Spinal Nerve Roots,
pubmed-meshheading:18996482-Statistics, Nonparametric,
pubmed-meshheading:18996482-Touch
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pubmed:year |
2009
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pubmed:articleTitle |
The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy.
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pubmed:affiliation |
Department of Neurology, University of Wuerzburg, Wuerzburg.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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