|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-2-2
|
|
pubmed:abstractText |
Inflammatory bowel diseases are relatively common diseases of the gastrointestinal tract. The relative therapeutic efficacy of glucocorticoids used in inflammatory bowel diseases resides in part in their capability to inhibit activity of nuclear factor kappaB (NF-kappaB), a transcription factor central to the inflammatory process, and the consequent production of T-helper 1 (Th1)-type cytokines. Previous studies indicate that increased expression in transgenic mice of glucocorticoid-induced leucine zipper (GILZ), a gene rapidly induced by glucocorticoids, inhibits NF-kappaB and Th1 activity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4-dinitrofluorobenzene sulfonic...,
http://linkedlifedata.com/resource/pubmed/chemical/Dinitrofluorobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/Dsip1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazolone,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1528-0012
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
136
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
530-41
|
|
pubmed:meshHeading |
pubmed-meshheading:18996377-Animals,
pubmed-meshheading:18996377-Colitis,
pubmed-meshheading:18996377-Colon,
pubmed-meshheading:18996377-Dinitrofluorobenzene,
pubmed-meshheading:18996377-Disease Models, Animal,
pubmed-meshheading:18996377-Genetic Predisposition to Disease,
pubmed-meshheading:18996377-Glucocorticoids,
pubmed-meshheading:18996377-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18996377-Interferon-gamma,
pubmed-meshheading:18996377-Interleukin-1,
pubmed-meshheading:18996377-Leucine Zippers,
pubmed-meshheading:18996377-Mice,
pubmed-meshheading:18996377-Mice, Knockout,
pubmed-meshheading:18996377-Mice, Transgenic,
pubmed-meshheading:18996377-NF-kappa B,
pubmed-meshheading:18996377-Oxazolone,
pubmed-meshheading:18996377-Th1 Cells,
pubmed-meshheading:18996377-Th2 Cells,
pubmed-meshheading:18996377-Transcription Factors,
pubmed-meshheading:18996377-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis.
|
|
pubmed:affiliation |
Department of Clinical and Experimental Medicine, Section of Pharmacology and Polo Scientifico e Didattico di Terni, University of Perugia, Perugia, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
