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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-11-10
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pubmed:abstractText |
The distal human gut is a microbial bioreactor that digests complex carbohydrates. The strategies evolved by gut microbes to sense and process diverse glycans have important implications for the assembly and operation of this ecosystem. The human gut-derived bacterium Bacteroides thetaiotaomicron forages on both host and dietary glycans. Its ability to target these substrates resides in 88 polysaccharide utilization loci (PULs), encompassing 18% of its genome. Whole genome transcriptional profiling and genetic tests were used to define the mechanisms underlying host glycan foraging in vivo and in vitro. PULs that target all major classes of host glycans were identified. However, mucin O-glycans are the principal host substrate foraged in vivo. Simultaneous deletion of five genes encoding ECF-sigma transcription factors, which activate mucin O-glycan utilization, produces defects in bacterial persistence in the gut and in mother-to-offspring transmission. Thus, PUL-mediated glycan catabolism is an important component in gut colonization and may impact microbiota ecology.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/DK30292,
http://linkedlifedata.com/resource/pubmed/grant/F32 AI073060,
http://linkedlifedata.com/resource/pubmed/grant/F32 AI073060-02,
http://linkedlifedata.com/resource/pubmed/grant/GM07200,
http://linkedlifedata.com/resource/pubmed/grant/HG00045,
http://linkedlifedata.com/resource/pubmed/grant/P30 DK056341-07,
http://linkedlifedata.com/resource/pubmed/grant/P30 DK056341-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK070977-07,
http://linkedlifedata.com/resource/pubmed/grant/R37 DK030292-27,
http://linkedlifedata.com/resource/pubmed/grant/T32 GM007200-34,
http://linkedlifedata.com/resource/pubmed/grant/T32 HD007409-15,
http://linkedlifedata.com/resource/pubmed/grant/T32 HD07409,
http://linkedlifedata.com/resource/pubmed/grant/T32 HG000045-09
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-10572122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-10852890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-10910972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-10986238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-15487947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-15853878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-15993072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-16033867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-16102597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-16332876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-16735464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-16788175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-16968696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-17183309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-17367380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-17455202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-17517967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-17579514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-17594176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-18184573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-18318598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-18541218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-4559821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-563214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-6782077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-7601836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-8150346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-848954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-8550519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18996345-9006015
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1934-6069
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-57
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:18996345-Animals,
pubmed-meshheading:18996345-Bacterial Proteins,
pubmed-meshheading:18996345-Bacteroides,
pubmed-meshheading:18996345-Female,
pubmed-meshheading:18996345-Gastrointestinal Tract,
pubmed-meshheading:18996345-Humans,
pubmed-meshheading:18996345-Intestinal Mucosa,
pubmed-meshheading:18996345-Male,
pubmed-meshheading:18996345-Mice,
pubmed-meshheading:18996345-Models, Biological,
pubmed-meshheading:18996345-Polysaccharides,
pubmed-meshheading:18996345-Swine,
pubmed-meshheading:18996345-Symbiosis
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pubmed:year |
2008
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pubmed:articleTitle |
Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont.
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pubmed:affiliation |
Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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