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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2009-1-2
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pubmed:abstractText |
The thiazolidinediones (TZDs) improve tissue sensitivity to insulin in patients with type II diabetes, resulting in reduced levels of fasting blood glucose and glycated hemoglobin. However, TZDs unpredictably demonstrate adverse effects of increased body weight, fluid retention, and edema. The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-3492
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
400
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-55
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pubmed:meshHeading |
pubmed-meshheading:18996102-Adult,
pubmed-meshheading:18996102-Aged,
pubmed-meshheading:18996102-Aged, 80 and over,
pubmed-meshheading:18996102-Body Mass Index,
pubmed-meshheading:18996102-Cross-Sectional Studies,
pubmed-meshheading:18996102-Drug Toxicity,
pubmed-meshheading:18996102-Edema,
pubmed-meshheading:18996102-Female,
pubmed-meshheading:18996102-Genomics,
pubmed-meshheading:18996102-Genotype,
pubmed-meshheading:18996102-Humans,
pubmed-meshheading:18996102-Hypoglycemic Agents,
pubmed-meshheading:18996102-Male,
pubmed-meshheading:18996102-Middle Aged,
pubmed-meshheading:18996102-Phenotype,
pubmed-meshheading:18996102-Polymorphism, Single Nucleotide,
pubmed-meshheading:18996102-Retrospective Studies,
pubmed-meshheading:18996102-Thiazolidinediones
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pubmed:year |
2009
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pubmed:articleTitle |
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
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pubmed:affiliation |
Genomas, Inc., 67 Jefferson St, Hartford, CT, United States. g.ruano@genomas.net
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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