Linked Life Data

18992767

Source:http://linkedlifedata.com/resource/pubmed/id/18992767

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-26
pubmed:abstractText
In order to better define the effects of methylmercury (MeHg) exposure on neurodevelopment, qualitative error types observed in the responses of exposed children to the Stanford-Binet Copying Test were categorized and quantified using raw data from two studies of 395 Amazonian children aged 7-12 years (from Brazil and French Guiana). These outcomes were related to hair-mercury concentration as the biomarker of MeHg exposure (range=0.5-63.8 microg/g). The combined analysis of data from two separate countries had two major goals: (1) to gain clues concerning the underlying neuropathological mechanisms of observed effects based on convergent evidence of MeHg-related qualitative outcomes in the two studies and (2) to explore possible cultural determinants of test response based on divergent outcomes in the two countries. Multiple linear and logistic regression analyses were performed with adjustment for confounders. In the combined data set, mercury exposure was negatively associated with scores on the drawing task: a score reduction of 1.2 (s.e., 0.3) points was observed in the children with a hair-mercury concentration above 10 microg/g compared to those with a hair level below 1 microg/g; this effect appeared to be stronger in the younger children. Risk of committing one or more errors of rotation, simplification or perseveration in the drawings increased with hair-mercury concentration in both cultural settings, providing convergent evidence of specific types of MeHg-related neurocognitive outcomes. However, relationships between mercury exposure and scores on the Block organization component of the test varied according to the study site, indicating that other factors must be considered in evaluating responses to the demands of this cognitive task.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-46
pubmed:dateRevised
2009-5-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Qualitative assessment of visuospatial errors in mercury-exposed Amazonian children.
pubmed:affiliation
Inserm, U625, University of Rennes I, GERHM, IFR140, F-35000 Rennes, France. cecile.chevrier@rennes.inserm.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't