| pubmed-article:18992226 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C1704336 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C0598783 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C0242697 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C2350345 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C0106127 | lld:lifeskim |
| pubmed-article:18992226 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:18992226 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18992226 | pubmed:dateCreated | 2008-11-28 | lld:pubmed |
| pubmed-article:18992226 | pubmed:abstractText | AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that has been implicated as a key factor for controlling intracellular lipids and glucose metabolism. Beta-sitosterol, a plant sterol known to prevent cardiovascular disease was identified from Schizonepeta tenuifolia to an AMPK activator. In L6 myotube cells, beta-sitosterol significantly increased phosphorylation of the AMPKalpha subunit and acetyl-CoA carboxylase (ACC) with stimulating glucose uptake. In contrast, beta-sitosterol treatment reduced intracellular levels of triglycerides and cholesterol in L6 cells. These effects were all reversed by pretreatment with AMPK inhibitor Compound C or LKB1 destabilizer radicicol. Similarly, beta-sitosterol-induced phosphorylation of AMPK and ACC was not increased in HeLa cells lacking LKB1. These results together suggest that beta-sitosterol-mediated enhancement of glucose uptake and reduction of triglycerides and cholesterol in L6 cells is predominantly accomplished by LKB1-mediated AMPK activation. Our findings further reveal a molecular mechanism underlying the beneficial effects of beta-sitosterol on glucose and lipid metabolism. | lld:pubmed |
| pubmed-article:18992226 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18992226 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18992226 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18992226 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18992226 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:HuhTae-LinTL | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:SongKyung-Sik... | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:KimJi-EunJE | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:KimHa-NaHN | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:SongHebokH | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:LeeJai-YoulJY | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:JungHyun-HeeH... | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:HurJong-MoonJ... | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:HwangSeung-La... | lld:pubmed |
| pubmed-article:18992226 | pubmed:author | pubmed-author:ChoiDong-KyuD... | lld:pubmed |
| pubmed-article:18992226 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18992226 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:18992226 | pubmed:volume | 377 | lld:pubmed |
| pubmed-article:18992226 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18992226 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18992226 | pubmed:pagination | 1253-8 | lld:pubmed |
| pubmed-article:18992226 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:18992226 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18992226 | pubmed:articleTitle | Beneficial effects of beta-sitosterol on glucose and lipid metabolism in L6 myotube cells are mediated by AMP-activated protein kinase. | lld:pubmed |
| pubmed-article:18992226 | pubmed:affiliation | TG Biotech Research Institute, Technobuilding, Kyungpook National University, Daegu 702-831, Republic of Korea. | lld:pubmed |
| pubmed-article:18992226 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18992226 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18992226 | lld:pubmed |
