Linked Life Data

18991953

Source:http://linkedlifedata.com/resource/pubmed/id/18991953

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-11-10
pubmed:abstractText
Astrocytes are a subpopulation of glial cells that directly affect neuronal function. This review focuses on the potential functional roles of astrocytes in the development of behavioral sensitization and rewarding effects induced by chronic treatment with drugs of abuse. In vitro treatment of cortical neuron/glia cocultures with either methamphetamine or morphine caused activation of astrocytes via protein kinase C (PKC). Purified cortical astrocytes were markedly activated by methamphetamine, whereas morphine had no such effect. Methamphetamine, but not morphine, caused a long-lasting astrocytic activation in cortical neuron/glia cocultures. Morphine-induced behavioral sensitization, assessed as hyperlocomotion, was reversed by 2 months of withdrawal from intermittent morphine administration, whereas behavioral sensitization to methamphetamine-induced hyperlocomotion was maintained even after 2 months of withdrawal. In vivo treatment with methamphetamine, which was associated with behavioral sensitization, caused PKC-dependent astrocytic activation in the mouse cingulate cortex and nucleus accumbens. Furthermore, the glial modulator propentofylline dramatically diminished the activation of astrocytes and the rewarding effect induced by methamphetamine and morphine. On the other hand, intra-nucleus accumbens and intra-cingulate cortex administration of astrocyte-conditioned medium aggravated the development of rewarding effects induced by methamphetamine and morphine. Furthermore, astrocyte-conditioned medium, but not methamphetamine itself, clearly induced differentiation of neural stem cells into astrocytes. These findings provide direct evidence that astrocytes may, at least in part, contribute to the development of the rewarding effects induced by drugs of abuse in the nucleus accumbens and cingulate cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-104
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18991953-Amphetamine-Related Disorders, pubmed-meshheading:18991953-Animals, pubmed-meshheading:18991953-Astrocytes, pubmed-meshheading:18991953-Cells, Cultured, pubmed-meshheading:18991953-Culture Media, Conditioned, pubmed-meshheading:18991953-Cytokines, pubmed-meshheading:18991953-Gyrus Cinguli, pubmed-meshheading:18991953-Humans, pubmed-meshheading:18991953-Janus Kinases, pubmed-meshheading:18991953-Methamphetamine, pubmed-meshheading:18991953-Mice, pubmed-meshheading:18991953-Morphine, pubmed-meshheading:18991953-Morphine Dependence, pubmed-meshheading:18991953-Motor Activity, pubmed-meshheading:18991953-Multipotent Stem Cells, pubmed-meshheading:18991953-Nerve Tissue Proteins, pubmed-meshheading:18991953-Neuronal Plasticity, pubmed-meshheading:18991953-Nucleus Accumbens, pubmed-meshheading:18991953-Protein Kinase C, pubmed-meshheading:18991953-Rats, pubmed-meshheading:18991953-Reward, pubmed-meshheading:18991953-STAT Transcription Factors, pubmed-meshheading:18991953-Signal Transduction
pubmed:year
2008
pubmed:articleTitle
Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine.
pubmed:affiliation
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan. narita@hoshi.ac.jp
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't