Source:http://linkedlifedata.com/resource/pubmed/id/18991688
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
26
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| pubmed:dateCreated |
2008-11-10
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| pubmed:abstractText |
We examined the relationship between moderate obesity and glucose metabolism, insulin sensitivity and suspected fatty liver in children. We measured body mass index (BMI), z-score BMI, caliper skinfold thickness, waist and hip circumference in 94 participants (mean age 9.7 +/-2.2 years). Fasting blood glucose, insulin, HOMA score, lipid profile and transaminases (ALT, AST) were measured. Fatty liver and skinfold thickness were evaluated by means of ultrasound. The z-score BMI was 2.01 +/-0.39 (mean +/- SD), and the duration of obesity was 4.3+/-3.03 years. A positive correlation was found between caliper and US skinfold thickness for tricipital (r= 0.33; p= 0.003) and sovrailiac skinfold (r= 0.34; p=0.003). Fatty liver was diagnosed in 64% of children and it was positively related to anthropometric measurements. The three sub-groups--group 0 (normal US liver and normal transaminases); group 1 (US fatty liver and normal transaminases); group 2 (US fatty liver and elevated transaminases)--showed a difference concerning z-score BMI, insulin and HOMA parameters (Tukey test: z score BMI group 1 vs group 0 and 2 vs group 0; serum insulin: group 2 vs group 1 and group 2 vs group 0; HOMA IR: group 2 vs group 1 and group 2 vs group 0). Moderately obese children with steatosis exhibited a clear increase of insulin and insulin resistance which represents indices of a future metabolic syndrome. In addition, it is important to perform a liver ultrasound since transaminases seems to be not adequate for the diagnosis of fatty liver.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1873-4286
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2693-8
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18991688-Adipose Tissue,
pubmed-meshheading:18991688-Blood Glucose,
pubmed-meshheading:18991688-Body Fat Distribution,
pubmed-meshheading:18991688-Body Mass Index,
pubmed-meshheading:18991688-Child,
pubmed-meshheading:18991688-Fatty Liver,
pubmed-meshheading:18991688-Female,
pubmed-meshheading:18991688-Homeostasis,
pubmed-meshheading:18991688-Humans,
pubmed-meshheading:18991688-Insulin,
pubmed-meshheading:18991688-Insulin Resistance,
pubmed-meshheading:18991688-Liver Function Tests,
pubmed-meshheading:18991688-Male,
pubmed-meshheading:18991688-Obesity,
pubmed-meshheading:18991688-Skinfold Thickness,
pubmed-meshheading:18991688-Transaminases
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| pubmed:year |
2008
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| pubmed:articleTitle |
Relationship among fatty liver, adipose tissue distribution and metabolic profile in moderately obese children: an ultrasonographic study.
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| pubmed:affiliation |
Radiology Unit, IRCCS S de Bellis, Via Turi, 70013 Castellana Grotte, BA, Italy. mchiloiro@libero.it
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| pubmed:publicationType |
Journal Article
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