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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2008-11-25
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pubmed:abstractText |
Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKalpha channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6386-9
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pubmed:meshHeading |
pubmed-meshheading:18990575-Animals,
pubmed-meshheading:18990575-CHO Cells,
pubmed-meshheading:18990575-Chemistry, Pharmaceutical,
pubmed-meshheading:18990575-Cricetinae,
pubmed-meshheading:18990575-Cricetulus,
pubmed-meshheading:18990575-Crystallography, X-Ray,
pubmed-meshheading:18990575-Diterpenes, Abietane,
pubmed-meshheading:18990575-Drug Design,
pubmed-meshheading:18990575-Ethers,
pubmed-meshheading:18990575-Hydrogen,
pubmed-meshheading:18990575-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:18990575-Models, Chemical,
pubmed-meshheading:18990575-Molecular Conformation,
pubmed-meshheading:18990575-Oximes,
pubmed-meshheading:18990575-Patch-Clamp Techniques
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pubmed:year |
2008
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pubmed:articleTitle |
Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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