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pubmed:abstractText |
Inhibition of Rho kinase (ROCK) is an attractive strategy for the treatment of diseases such as hypertension, glaucoma, and cancer. Here we report chroman-3-amides as highly potent ROCK inhibitors with sufficient kinase selectivity, excellent cell activity, good microsomal stability, and desirable pharmacokinetic properties for study as potential therapeutic agents.
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pubmed:affiliation |
Department of Molecular Therapeutics, The Scripps Research Institute, Florida, 130 Scripps Way, #2A1, Jupiter, FL 33458, USA.
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