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rdf:type |
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lifeskim:mentions |
umls-concept:C0001721,
umls-concept:C0003289,
umls-concept:C0007407,
umls-concept:C0025646,
umls-concept:C0042285,
umls-concept:C0070122,
umls-concept:C0542559,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2009-2-16
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pubmed:abstractText |
The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidepressant response gave contrasting results.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
203
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-60
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pubmed:meshHeading |
pubmed-meshheading:18989660-Adult,
pubmed-meshheading:18989660-Antidepressive Agents, Second-Generation,
pubmed-meshheading:18989660-Catechol O-Methyltransferase,
pubmed-meshheading:18989660-Catecholamines,
pubmed-meshheading:18989660-Depressive Disorder, Major,
pubmed-meshheading:18989660-Female,
pubmed-meshheading:18989660-Heterozygote,
pubmed-meshheading:18989660-Homozygote,
pubmed-meshheading:18989660-Humans,
pubmed-meshheading:18989660-Male,
pubmed-meshheading:18989660-Middle Aged,
pubmed-meshheading:18989660-Paroxetine,
pubmed-meshheading:18989660-Polymorphism, Genetic,
pubmed-meshheading:18989660-Psychiatric Status Rating Scales,
pubmed-meshheading:18989660-Serotonin Uptake Inhibitors,
pubmed-meshheading:18989660-Severity of Illness Index,
pubmed-meshheading:18989660-Time Factors,
pubmed-meshheading:18989660-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting.
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pubmed:affiliation |
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy. benedetti.francesco@hsr.it
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pubmed:publicationType |
Journal Article
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