Source:http://linkedlifedata.com/resource/pubmed/id/18989468
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2008-11-7
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| pubmed:abstractText |
Cadherins are a family of transmembrane glycoproteins that mediate cell-to-cell adhesion. Isoforms, including E- and N-cadherin, have been identified and shown to regulate morphogenesis through homophilic binding. In the ontogeny, the expressions of E- and N-cadherin change spatiotemporally, and the changes in cadherin isoforms, called cadherin switching, impact the mechanical adhesion of cells. Furthermore, cadherin functions as a receptor that transfers information from outside to inside cells, and in terms of switching, it affects cell phenotypes. To observe the expression patterns of E- and N-cadherins during embryogenesis and to identify cells that transiently coexpress both cadherins, we employed a recently developed immunohistochemical double staining technique in rat fetuses. At embryonic day 9, embryonic ectodermal cells more dominantly expressed E-cadherin, while mesodermal cells more dominantly expressed N-cadherin. At embryonic day 10, the expression pattern of E-cadherin in the surface ectoderm and endoderm and that of N-cadherin in the neuroectoderm were established. After embryonic day 10, unique co-expression of E- and N-cadherin was observed in primordia, such as the bulbus cordis, otic pit, notochord, and Rathke's pouch. In the present study, it was possible to visualize the expression patterns of E- and N-cadherin during early fetal development, which enabled us to morphologically clarify cadherin switching.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-10739670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-10969083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-11171330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-12126948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-12640664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-12915661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-1315697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-16819153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-17138661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-17373711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-17654718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-18322269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-2197976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-3416359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-3817290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-8714286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-8898231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-9169046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18989468-9352199
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0044-5991
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
29
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| pubmed:volume |
41
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
143-7
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| pubmed:dateRevised |
2009-11-18
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| pubmed:year |
2008
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| pubmed:articleTitle |
Immunohistochemical observation of co-expression of E- and N-cadherins in rat organogenesis.
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| pubmed:affiliation |
Division of Forensic Medicine, Center for Community Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. atsushis@jichi.ac.jp
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| pubmed:publicationType |
Journal Article
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