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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-2-20
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pubmed:abstractText |
These studies demonstrate that the cytotoxic activity of splenic natural killer (NK) cells is augmented in both nu/nu and nu/+ mice during systemic cryptococcosis. Both the kinetics and the regulation of NK cell activity differed in Cryptococcus neoformans-infected nu/nu and nu/+ mice. Greater augmentation was observed following challenge with 10(5) cells than with smaller inocula, and augmented NK cell activity was not always associated with enhanced control of systemic cryptococcosis. Infection with a nonencapsulated strain of C. neoformans induced an early but transient increase in splenic NK cell activity in nu/nu and nu/+ mice. Injection of capsular polysaccharide induced a transient augmentation of splenic NK cell activity in nu/+ mice but caused a persistent increase in splenic NK cell activity in nu/nu mice. In vivo treatment with monoclonal antibody to gamma interferon abrogated the augmentation of splenic NK cell activity induced during cryptococcal infections in both nu/nu and nu/+ mice and enhanced the susceptibility of nu/+ mice to C. neoformans to a greater extent than it did that of nu/nu mice. These results suggest that gamma interferon is an important mediator of resistance to C. neoformans.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-16557771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-1968837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2114368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2411797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2496162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2524098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2642471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2647836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2659531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2663363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-2680980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-3112223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-313367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-3138176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-338489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-3510251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-3510981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-3537121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-367954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-3899938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-3928681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-4553080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-4553084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-4564405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-6057803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-6120974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898905-6341580
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
486-93
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:1898905-Animals,
pubmed-meshheading:1898905-Antibodies, Monoclonal,
pubmed-meshheading:1898905-Cryptococcosis,
pubmed-meshheading:1898905-Cryptococcus neoformans,
pubmed-meshheading:1898905-Cytotoxicity, Immunologic,
pubmed-meshheading:1898905-Interferon-gamma,
pubmed-meshheading:1898905-Killer Cells, Natural,
pubmed-meshheading:1898905-Macrophages,
pubmed-meshheading:1898905-Mice,
pubmed-meshheading:1898905-Mice, Inbred BALB C,
pubmed-meshheading:1898905-Mice, Nude,
pubmed-meshheading:1898905-Polysaccharides, Bacterial,
pubmed-meshheading:1898905-Spleen
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pubmed:year |
1991
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pubmed:articleTitle |
A monoclonal antibody to gamma interferon blocks augmentation of natural killer cell activity induced during systemic cryptococcosis.
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pubmed:affiliation |
Department of Surgery, University of Wisconsin Medical School, Madison 53706.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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