| pubmed-article:1898873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:1898873 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:1898873 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1898873 | pubmed:dateCreated | 1991-2-20 | lld:pubmed |
| pubmed-article:1898873 | pubmed:abstractText | Immature thymocytes, which coexpress CD4 and CD8, give rise to mature CD4+CD8- and CD4-CD8+ T cells. Only those T cells that recognize self-MHC are selected to mature, a process known as positive selection. The specificity of the T cell antigen receptor (TCR) for class I or class II MHC influences the commitment to a CD4 or CD8 lineage. This may occur by a directed mechanism or by stochastic commitment followed by a selection step that allows only CD8+, class I-specific and CD4+, class II-specific cells to survive. We have generated a mouse line expressing a CD8 transgene under the control of the T cell-specific CD2 regulatory sequences. Although constitutive CD8 expression does not affect thymic selection of CD4+ cells, selection of a class I-specific TCR in the CD8 subset is substantially improved. This outcome is consistent with a model for positive selection in which selection occurs at a developmental stage in which both CD4 and CD8 are expressed, and positive selection by class I MHC generates an instructive signal that directs differentiation to a CD8 lineage. | lld:pubmed |
| pubmed-article:1898873 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1898873 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1898873 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1898873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1898873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1898873 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1898873 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1898873 | pubmed:author | pubmed-author:von BoehmerHH | lld:pubmed |
| pubmed-article:1898873 | pubmed:author | pubmed-author:AxelRR | lld:pubmed |
| pubmed-article:1898873 | pubmed:author | pubmed-author:KioussisDD | lld:pubmed |
| pubmed-article:1898873 | pubmed:author | pubmed-author:FowlkesB JBJ | lld:pubmed |
| pubmed-article:1898873 | pubmed:author | pubmed-author:GordonJ WJW | lld:pubmed |
| pubmed-article:1898873 | pubmed:author | pubmed-author:RamsdellFF | lld:pubmed |
| pubmed-article:1898873 | pubmed:author | pubmed-author:RobeyE AEA | lld:pubmed |
| pubmed-article:1898873 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1898873 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:1898873 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:1898873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1898873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1898873 | pubmed:pagination | 99-107 | lld:pubmed |
| pubmed-article:1898873 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1898873 | pubmed:meshHeading | pubmed-meshheading:1898873-... | lld:pubmed |
| pubmed-article:1898873 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1898873 | pubmed:articleTitle | Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. | lld:pubmed |
| pubmed-article:1898873 | pubmed:affiliation | Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032. | lld:pubmed |
| pubmed-article:1898873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1898873 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1898873 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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