Linked Life Data

18987940

Source:http://linkedlifedata.com/resource/pubmed/id/18987940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-11-6
pubmed:abstractText
Primary lymphoma of the gallbladder is an exceedingly rare disease. We experienced an asymptomatic case of primary non-Hodgkin's lymphoma of the gallbladder in a 55-year-old woman in whom laparoscopic cholecystectomy made a definite diagnosis. Abdominal computed tomography revealed a 4-cm gallbladder tumor with markedly enlarged lymph nodes in the retropancreatic area. Despite the marked involvement of lymph nodes, serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 were not elevated. The discrepancy between the imaging findings and the patient's mild clinical presentation led us to suspect that the tumor was a lymphoma. We examined serum markers of lymphoma, revealing slight elevations of interleukin (IL)-2 receptor and thymidine kinase. Laparoscopic cholecystectomy for a total biopsy was performed successfully, and the results of intraoperative frozen-section examination led us to have a high suspicion of malignant lymphoma. The final diagnosis was large diffuse B-cell lymphoma of the gallbladder with a positive CD20 antibody reaction. The patient received postoperative chemotherapy with R-CHOP (rituximab, 500 mg; cyclophosphamide, 1000 mg; adriamycin, 68 mg; vincristine, 1.9 mg; and prednisone, 80 mg) starting on postoperative day 12. She achieved complete remission and is still in complete remission 3 years and 2 months after the cholecystectomy. In conclusion, gallbladder lymphoma should be added to the differential diagnosis of gallbladder tumors, especially when the imaging findings and clinical presentation are not consistent with typical signs of gallbladder carcinoma, and laparoscopic cholecystectomy is helpful for the confirmation of suspicious cases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0944-1166
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
659-63
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18987940-Antibodies, Monoclonal, pubmed-meshheading:18987940-Antibodies, Monoclonal, Murine-Derived, pubmed-meshheading:18987940-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:18987940-Cholecystectomy, Laparoscopic, pubmed-meshheading:18987940-Combined Modality Therapy, pubmed-meshheading:18987940-Cyclophosphamide, pubmed-meshheading:18987940-Doxorubicin, pubmed-meshheading:18987940-Female, pubmed-meshheading:18987940-Gallbladder Neoplasms, pubmed-meshheading:18987940-Humans, pubmed-meshheading:18987940-Lymphatic Metastasis, pubmed-meshheading:18987940-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:18987940-Middle Aged, pubmed-meshheading:18987940-Prednisone, pubmed-meshheading:18987940-Tomography, X-Ray Computed, pubmed-meshheading:18987940-Tumor Markers, Biological, pubmed-meshheading:18987940-Vincristine
pubmed:year
2008
pubmed:articleTitle
Primary non-Hodgkin's lymphoma of the gallbladder diagnosed by laparoscopic cholecystectomy.
pubmed:affiliation
Department of Surgery, Saiseikai Matsusaka General Hospital, Mie, Japan.
pubmed:publicationType
Journal Article, Case Reports