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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-9
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918410,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918411,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918412,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918413,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918414,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918415,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918416,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918417,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918418,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918419,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918420,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918421,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918422,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918423,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918424,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918425,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918426,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EU918427
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pubmed:abstractText |
The origin of allelic polymorphism in genes of the major histocompatibility complex represents a central topic in evolutionary genetics as it is probably the most polymorphic region in the nuclear genome of vertebrates. Accordingly, the analyses of genetic variability at these loci provide evidence complementary to the population genetics studies based on neutral loci. In this study, four wild boar populations, two from Italy (Florence region and Castelporziano Presidential Reserve, outside Rome) and one each from Hungary and Poland, were characterized at a highly polymorphic fragment including part of intron 1 and exon 2 of swine leukocyte antigen (SLA) class II DRB1 gene by direct sequencing and by cloning. Excluding the false alleles, a total of 18 different sequences were observed in 57 individuals. The high ratio of nonsynonymous (dN) vs synonymous (dS) substitution rates in the peptide-binding region supports the hypothesis that balancing selection is operating at this locus. A duplication event at the DRB1 gene was documented only in one Italian population with both copies being putatively active. This is the first evidence of a polymorphism for the number of copies of an SLA gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1432-1211
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18987853-Amino Acid Sequence,
pubmed-meshheading:18987853-Amino Acid Substitution,
pubmed-meshheading:18987853-Animals,
pubmed-meshheading:18987853-Animals, Wild,
pubmed-meshheading:18987853-Binding Sites,
pubmed-meshheading:18987853-Conserved Sequence,
pubmed-meshheading:18987853-Exons,
pubmed-meshheading:18987853-Gene Duplication,
pubmed-meshheading:18987853-Genes, MHC Class II,
pubmed-meshheading:18987853-Genetic Variation,
pubmed-meshheading:18987853-Hungary,
pubmed-meshheading:18987853-Introns,
pubmed-meshheading:18987853-Italy,
pubmed-meshheading:18987853-Molecular Sequence Data,
pubmed-meshheading:18987853-Poland,
pubmed-meshheading:18987853-Polymorphism, Genetic,
pubmed-meshheading:18987853-Selection, Genetic,
pubmed-meshheading:18987853-Sequence Alignment,
pubmed-meshheading:18987853-Sequence Homology, Amino Acid,
pubmed-meshheading:18987853-Sus scrofa
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pubmed:year |
2009
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pubmed:articleTitle |
Duplication polymorphism at MHC class II DRB1 locus in the wild boar (Sus scrofa).
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pubmed:affiliation |
Department of Biology, University of Padua, Padua, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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