Linked Life Data

18987668

Source:http://linkedlifedata.com/resource/pubmed/id/18987668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-16
pubmed:abstractText
The primary cilium is a microtubule-based organelle implicated as an essential component of a number of signaling pathways. It is present on cells throughout the mammalian body; however, its functions in most tissues remain largely unknown. Herein we demonstrate that primary cilia are present on cells in murine skin and hair follicles throughout morphogenesis and during hair follicle cycling in postnatal life. Using the Cre-lox system, we disrupted cilia assembly in the ventral dermis and evaluated the effects on hair follicle development. Mice with disrupted dermal cilia have severe hypotrichosis (lack of hair) in affected areas. Histological analyses reveal that most follicles in the mutants arrest at stage 2 of hair development and have small or absent dermal condensates. This phenotype is reminiscent of that seen in the skin of mice lacking Shh or Gli2. In situ hybridization and quantitative RT-PCR analysis indicates that the hedgehog pathway is downregulated in the dermis of the cilia mutant hair follicles. Thus, these data establish cilia as a critical signaling component required for normal hair morphogenesis and suggest that this organelle is needed on cells in the dermis for reception of signals such as sonic hedgehog.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-10331973, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-10363364, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-10804177, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-10943838, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-11251073, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-11520664, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-11742814, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-11972351, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-12112875, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-12235001, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-12533516, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-12743034, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-12828684, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-12949776, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-14001080, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-15226261, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-15580285, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-15617561, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-1566372, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-15714560, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-15852005, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-15930098, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16054035, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16061793, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16136078, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16229832, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16243034, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16254602, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16275743, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16609290, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16725313, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-16888132, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-17027958, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-17166921, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-17199044, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-17241444, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-17641202, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-17804638, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-18084282, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-18480165, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-18539925, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-19148215, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-1958381, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-2415535, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-2879846, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-4533198, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-6085808, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-6719981, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-7131649, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-8964046, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-9108056, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-9176412, http://linkedlifedata.com/resource/pubmed/commentcorrection/18987668-9768360
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1523-1747
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
438-48
pubmed:dateRevised
2010-9-22
pubmed:meshHeading
More...