Linked Life Data

18987456

Source:http://linkedlifedata.com/resource/pubmed/id/18987456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-11-6
pubmed:abstractText
Diabetic patients have a decreased incidence of acute respiratory distress syndrome, but the mechanism responsible for the decreased incidence is uncertain. Reabsorption of alveolar edema fluid (alveolar fluid clearance) has been considered to play an important role in resolution of acute respiratory distress syndrome. However, little is known regarding alveolar fluid clearance in diabetes mellitus. Since the obese Zucker rat has been used as an experimental model for diabetes mellitus, we determined if alveolar fluid clearance increased in the obese Zucker rat. First, we compared alveolar fluid clearance in obese Zucker rats with that in lean Zucker rats and Sprague-Dawley (SD) rats. Then, we determined the role of sodium channel, Na,K-ATPase, and beta(2)-adrenoceptor, which drives alveolar fluid clearance, in obese Zucker rats. Alveolar fluid clearance was estimated by the progressive increase in alveolar albumin concentrations in the isolated lungs. We found that basal alveolar fluid clearance in obese Zucker rats was two-fold greater than that in lean Zucker rats and SD rats. The mRNA expression of alpha(1)-, beta(1)-Na, K-ATPase and beta(2)-adrenoceptor, but not mRNA expression of sodium channel, increased in obese Zucker rats. A selective beta(2)-agrenergic antagonist, but not a Na, K-ATPase inhibitor, specifically inhibited the increase in alveolar fluid clearance in obese Zucker rats. These results indicate that overexpression of beta(2)-adrenoceptor primarily increases basal alveolar fluid clearance in the obese Zucker rat. We speculate that the stimulation of alveolar fluid clearance ameliorates acute respiratory distress syndrome in patients with diabetes mellitus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1349-3329
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-30
pubmed:meshHeading
pubmed-meshheading:18987456-Absorption, pubmed-meshheading:18987456-Adrenergic beta-Agonists, pubmed-meshheading:18987456-Adrenergic beta-Antagonists, pubmed-meshheading:18987456-Amiloride, pubmed-meshheading:18987456-Animals, pubmed-meshheading:18987456-Body Fluids, pubmed-meshheading:18987456-Edema, pubmed-meshheading:18987456-Epithelial Sodium Channel, pubmed-meshheading:18987456-Extravascular Lung Water, pubmed-meshheading:18987456-Gene Expression Regulation, pubmed-meshheading:18987456-Obesity, pubmed-meshheading:18987456-Organ Size, pubmed-meshheading:18987456-Ouabain, pubmed-meshheading:18987456-Pulmonary Alveoli, pubmed-meshheading:18987456-RNA, Messenger, pubmed-meshheading:18987456-Rats, pubmed-meshheading:18987456-Rats, Sprague-Dawley, pubmed-meshheading:18987456-Rats, Zucker, pubmed-meshheading:18987456-Receptors, Adrenergic, beta-2, pubmed-meshheading:18987456-Sodium-Potassium-Exchanging ATPase, pubmed-meshheading:18987456-Thinness
pubmed:year
2008
pubmed:articleTitle
Increased reabsorption of alveolar edema fluid in the obese Zucker rat.
pubmed:affiliation
Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't