|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1991-2-1
|
|
pubmed:abstractText |
The membrane immunoglobulin heavy chain (micron) plays a feedback role during the pre-B stage of B lymphocyte differentiation. In pre-B cell lines, micron associates with two surrogate light chain proteins. The omega chain is disulfide linked to mu and was predicted to be the product of the lambda 5 gene. The iota chain is noncovalently associated with micron. We demonstrate that the omega protein is indeed the product of the lambda 5 gene and that mu, omega, and iota are coassociated in the same complex. Antibodies against the omega/lambda 5 protein demonstrate the existence of a subpopulation of "transitional" bone marrow B cells that express micron and omega on the cell surface. The majority of these cells also express surface kappa light chains, indicating that in B lymphoid ontogeny the lambda 5 gene is inactivated after the onset of kappa light chain expression.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-112480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2114976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2117638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2117639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2154371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-222460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2304550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2430794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2463161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2501791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-2518725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3024017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3081897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3114643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3117530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3118373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3133444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3137575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3138073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3139821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3264786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3920529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3926323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3926483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-3930970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-6418805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-6789213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1898658-6982733
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
173
|
|
pubmed:geneSymbol |
&lgr;5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
111-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1898658-Amino Acid Sequence,
pubmed-meshheading:1898658-B-Lymphocytes,
pubmed-meshheading:1898658-Bone Marrow Cells,
pubmed-meshheading:1898658-Cell Differentiation,
pubmed-meshheading:1898658-Gene Expression Regulation,
pubmed-meshheading:1898658-Immunoglobulin Light Chains,
pubmed-meshheading:1898658-Immunoglobulin Light Chains, Surrogate,
pubmed-meshheading:1898658-Immunoglobulin kappa-Chains,
pubmed-meshheading:1898658-Immunoglobulin lambda-Chains,
pubmed-meshheading:1898658-Immunoglobulin mu-Chains,
pubmed-meshheading:1898658-Membrane Glycoproteins,
pubmed-meshheading:1898658-Molecular Sequence Data,
pubmed-meshheading:1898658-Spleen
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.
|
|
pubmed:affiliation |
Molecular Immunology Laboratory, Cancer Center of Massachusetts General Hospital, Boston.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
