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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-11-26
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pubmed:abstractText |
Signaling defects in the Toll-like receptor (TLR) pathway, such as interleukin-1 receptor-associated kinase 4 deficiency, highlight the prominence of TLR signaling in the defense against bacterial disease. Because myeloid differentiation primary response gene 88 (MyD88) can transduce signals from almost all TLRs, we studied its role in otitis media (OM), the most common upper respiratory tract bacterial infectious disease in young children.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:BroideDavid HDH,
pubmed-author:EbmeyerJoergJ,
pubmed-author:EuteneuerSaraS,
pubmed-author:GuineyDonald GDG,
pubmed-author:HernandezMichelleM,
pubmed-author:LeichtleAnkeA,
pubmed-author:ObonyoMarygorretM,
pubmed-author:PakKwangK,
pubmed-author:RyanAllen FAF,
pubmed-author:WassermanStephen ISI,
pubmed-author:WebsterNicholas JNJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
198
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1862-9
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pubmed:meshHeading |
pubmed-meshheading:18986247-Animals,
pubmed-meshheading:18986247-Anti-Bacterial Agents,
pubmed-meshheading:18986247-Ear, Middle,
pubmed-meshheading:18986247-Gene Expression Regulation,
pubmed-meshheading:18986247-Gentamicins,
pubmed-meshheading:18986247-Haemophilus Infections,
pubmed-meshheading:18986247-Haemophilus influenzae,
pubmed-meshheading:18986247-Mice,
pubmed-meshheading:18986247-Mice, Inbred C57BL,
pubmed-meshheading:18986247-Mice, Knockout,
pubmed-meshheading:18986247-Myeloid Differentiation Factor 88,
pubmed-meshheading:18986247-Otitis Media
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pubmed:year |
2008
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pubmed:articleTitle |
Myeloid differentiation primary response gene 88 is required for the resolution of otitis media.
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pubmed:affiliation |
Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, and Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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