Linked Life Data

18985293

Source:http://linkedlifedata.com/resource/pubmed/id/18985293

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-11-5
pubmed:abstractText
Decomposition of schizophrenia into neurobiological vulnerability traits is necessary to understand the complex genetic underpinnings of this phenomenologically defined disorder. This issue is discussed with a focus on prepulse inhibition (PPI) as a neurobiological phenotype and the 5HT2a-receptor as a candidate gene. A series of recent studies illuminates that PPI and 5HT2a-receptors present as vulnerability markers for schizophrenia; a functional sequence variant in the 5HT2a-gene is contributing to this relationship and might consequently contribute to the genetic predisposition to schizophrenia with a very small risk increase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0940-1334
pubmed:author
pubmed:issnType
Print
pubmed:volume
258 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-3
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia.
pubmed:affiliation
Klinik und Poliklinik für Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany. Wolfgang.Maier@ukb.uni-bonn.de
pubmed:publicationType
Journal Article, Review