Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-10-22
|
| pubmed:abstractText |
The 3,3'-[omega,omega'-alkanediylbis(oxy)]bis[2- (hydroxyimino)methyl]-1-methylpyridinium derivatives bearing a linking chain of 4, 5 and 6 methylene groups are accumulated in mitochondria with increasing efficiency under the effect of the electrical potential. Accumulation does not take place with derivatives carrying a 2 and 3 methylene-long linking chain. The uptake process is saturable. The efficiency of the various derivatives to induce the "petite" phenotype in yeast reflects the uptake rate observed with purified mitochondria.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
179
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
992-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1898417-DNA, Mitochondrial,
pubmed-meshheading:1898417-DNA Damage,
pubmed-meshheading:1898417-Hydrocarbons,
pubmed-meshheading:1898417-Kinetics,
pubmed-meshheading:1898417-Membrane Potentials,
pubmed-meshheading:1898417-Mitochondria,
pubmed-meshheading:1898417-Oxygen Consumption,
pubmed-meshheading:1898417-Phenotype,
pubmed-meshheading:1898417-Pyridinium Compounds,
pubmed-meshheading:1898417-Saccharomyces cerevisiae
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Mitochondrial uptake of bridged bis-methylpyridinium aldoximes and induction of the "petite" phenotype in yeast.
|
| pubmed:affiliation |
Institut de Topologie et de Dynamique des Systèmes, Université Paris 7, CNRS URA 34, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|