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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-2-27
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pubmed:abstractText |
Genomic instability participates in the pathogenesis of hepatocellular carcinoma (HCC). Apurinic/apyrimidinic endonuclease 1 (APEX1) participates in the base excision repair of premutagenic apurinic/apyrimidinic (AP) sites. Mice deficient in methionine adenosyltransferase 1a (Mat1a KO) have chronic hepatic deficiency of S-adenosylmethionine (SAMe) and increased oxidative stress, and develop HCC. We examined livers of Mat1a KO mice for genomic instability and dysregulation of APEX1.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1025-36
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pubmed:meshHeading |
pubmed-meshheading:18983843-Animals,
pubmed-meshheading:18983843-Carcinoma, Hepatocellular,
pubmed-meshheading:18983843-Cells, Cultured,
pubmed-meshheading:18983843-DNA-(Apurinic or Apyrimidinic Site) Lyase,
pubmed-meshheading:18983843-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18983843-Genomic Instability,
pubmed-meshheading:18983843-Hepatocytes,
pubmed-meshheading:18983843-Humans,
pubmed-meshheading:18983843-Liver Neoplasms,
pubmed-meshheading:18983843-Male,
pubmed-meshheading:18983843-Methionine Adenosyltransferase,
pubmed-meshheading:18983843-Mice,
pubmed-meshheading:18983843-Mice, Inbred C57BL,
pubmed-meshheading:18983843-Mice, Knockout,
pubmed-meshheading:18983843-S-Adenosylmethionine,
pubmed-meshheading:18983843-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.
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pubmed:affiliation |
Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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