| pubmed-article:18983329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C2745888 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:18983329 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:18983329 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18983329 | pubmed:dateCreated | 2008-11-5 | lld:pubmed |
| pubmed-article:18983329 | pubmed:abstractText | Elevated plasma triglyceride/free fatty acid (FFA) levels and insulin resistance may promote atherosclerosis through endothelial activation (ie, increased expression of intercellular adhesion molecule 1 [ICAM-1]/vascular adhesion molecule 1 [VCAM-1], and endothelin-1 [ET-1]) in patients with the metabolic syndrome, but this has never been directly tested. The authors measured endothelial activation and insulin sensitivity (euglycemic insulin clamp with [3-(3)H]-glucose) after a 4-day low-dose lipid infusion that elevated plasma FFA to levels observed in the metabolic syndrome in 20 lean, non-diabetic insulin-resistant subjects with a strong family history of type 2 diabetes mellitus (FH(+)) and 10 insulin-sensitive volunteers without a family history of type 2 diabetes mellitus (FH(-)). Low-dose lipid infusion reduced insulin sensitivity by approximately 25% in insulin-sensitive FH(-)controls but did not worsen preexisting insulin resistance in FH(+). Low-dose lipid infusion elevated plasma ICAM and VCAM levels similarly in both groups (approximately 12%-18%; P<.01 vs baseline), while plasma ET-1 levels increased more in FH(+)vs FH(-)(46% vs 10%; P=.005). Increased plasma FFA levels closely correlated with elevated ICAM (r=0.60; P<.01), VCAM, and ET-1 levels (r=0.39 and r=0.42, respectively; P<.05). Low-dose lipid infusion induces endothelial activation in both lean insulin-resistant (FH(+)) and insulin-sensitive (FH(-)) healthy patients, regardless of changes in insulin sensitivity. These results prove that even a modest lipid oversupply may be sufficient to trigger a deleterious endothelial response. | lld:pubmed |
| pubmed-article:18983329 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18983329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18983329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18983329 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18983329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18983329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18983329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18983329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18983329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18983329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18983329 | pubmed:issn | 1559-4564 | lld:pubmed |
| pubmed-article:18983329 | pubmed:author | pubmed-author:CusiKennethK | lld:pubmed |
| pubmed-article:18983329 | pubmed:author | pubmed-author:BelfortRenata... | lld:pubmed |
| pubmed-article:18983329 | pubmed:author | pubmed-author:LeeShukoS | lld:pubmed |
| pubmed-article:18983329 | pubmed:author | pubmed-author:CersosimoEuge... | lld:pubmed |
| pubmed-article:18983329 | pubmed:author | pubmed-author:KashyapSangee... | lld:pubmed |
| pubmed-article:18983329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18983329 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:18983329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18983329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18983329 | pubmed:pagination | 141-6 | lld:pubmed |
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| pubmed-article:18983329 | pubmed:meshHeading | pubmed-meshheading:18983329... | lld:pubmed |
| pubmed-article:18983329 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18983329 | pubmed:articleTitle | Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects. | lld:pubmed |
| pubmed-article:18983329 | pubmed:affiliation | Division of Diabetes, University of Texas Health Science Center, San Antonio, TX 78284-3900, USA. | lld:pubmed |
| pubmed-article:18983329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18983329 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18983329 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18983329 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18983329 | lld:pubmed |
