Source:http://linkedlifedata.com/resource/pubmed/id/18983329
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-11-5
|
| pubmed:abstractText |
Elevated plasma triglyceride/free fatty acid (FFA) levels and insulin resistance may promote atherosclerosis through endothelial activation (ie, increased expression of intercellular adhesion molecule 1 [ICAM-1]/vascular adhesion molecule 1 [VCAM-1], and endothelin-1 [ET-1]) in patients with the metabolic syndrome, but this has never been directly tested. The authors measured endothelial activation and insulin sensitivity (euglycemic insulin clamp with [3-(3)H]-glucose) after a 4-day low-dose lipid infusion that elevated plasma FFA to levels observed in the metabolic syndrome in 20 lean, non-diabetic insulin-resistant subjects with a strong family history of type 2 diabetes mellitus (FH(+)) and 10 insulin-sensitive volunteers without a family history of type 2 diabetes mellitus (FH(-)). Low-dose lipid infusion reduced insulin sensitivity by approximately 25% in insulin-sensitive FH(-)controls but did not worsen preexisting insulin resistance in FH(+). Low-dose lipid infusion elevated plasma ICAM and VCAM levels similarly in both groups (approximately 12%-18%; P<.01 vs baseline), while plasma ET-1 levels increased more in FH(+)vs FH(-)(46% vs 10%; P=.005). Increased plasma FFA levels closely correlated with elevated ICAM (r=0.60; P<.01), VCAM, and ET-1 levels (r=0.39 and r=0.42, respectively; P<.05). Low-dose lipid infusion induces endothelial activation in both lean insulin-resistant (FH(+)) and insulin-sensitive (FH(-)) healthy patients, regardless of changes in insulin sensitivity. These results prove that even a modest lipid oversupply may be sufficient to trigger a deleterious endothelial response.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1559-4564
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
141-6
|
| pubmed:meshHeading |
pubmed-meshheading:18983329-Adult,
pubmed-meshheading:18983329-Biological Markers,
pubmed-meshheading:18983329-Blood Glucose,
pubmed-meshheading:18983329-Dose-Response Relationship, Drug,
pubmed-meshheading:18983329-Endothelin-1,
pubmed-meshheading:18983329-Endothelium, Vascular,
pubmed-meshheading:18983329-Female,
pubmed-meshheading:18983329-Follow-Up Studies,
pubmed-meshheading:18983329-Glucose Tolerance Test,
pubmed-meshheading:18983329-Humans,
pubmed-meshheading:18983329-Infusions, Intravenous,
pubmed-meshheading:18983329-Insulin Resistance,
pubmed-meshheading:18983329-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18983329-Lipids,
pubmed-meshheading:18983329-Male,
pubmed-meshheading:18983329-Metabolic Syndrome X,
pubmed-meshheading:18983329-Prognosis,
pubmed-meshheading:18983329-Reference Values,
pubmed-meshheading:18983329-Vascular Cell Adhesion Molecule-1
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects.
|
| pubmed:affiliation |
Division of Diabetes, University of Texas Health Science Center, San Antonio, TX 78284-3900, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|