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rdf:type |
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lifeskim:mentions |
umls-concept:C0003864,
umls-concept:C0004379,
umls-concept:C0017262,
umls-concept:C0023688,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0287186,
umls-concept:C0441722,
umls-concept:C0442108,
umls-concept:C0449258,
umls-concept:C2911684
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pubmed:issue |
11
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pubmed:dateCreated |
2008-11-4
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pubmed:abstractText |
One of the hallmarks of rheumatoid arthritis (RA) is hyperplasia and inflammation of the synovial tissue being characterized by in situ occurrence of highly differentiated leukocytes. Fms-like tyrosine kinase 3 (Flt3) has a crucial role in hematopoiesis, regulation of cell proliferation, differentiation and apoptosis. Typically, Flt3 is expressed on early myeloid and lymphoid progenitors and is activated by its soluble ligand (Flt3-L). The highly differentiated cellular pattern in the synovium of the RA patients made us hypothesize that Flt3-L, with its ability to induce proliferation and differentiation, could be of importance in induction and/or progression of arthritis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-10910900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-11675341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-11714392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-12748655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-12951584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-3358796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-8394751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-8608220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-8634436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-8637232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-9207445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18982072-9226162
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e3633
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18982072-Adjuvants, Immunologic,
pubmed-meshheading:18982072-Adult,
pubmed-meshheading:18982072-Aged,
pubmed-meshheading:18982072-Aged, 80 and over,
pubmed-meshheading:18982072-Animals,
pubmed-meshheading:18982072-Arthritis, Rheumatoid,
pubmed-meshheading:18982072-B-Lymphocytes,
pubmed-meshheading:18982072-Bacterial Proteins,
pubmed-meshheading:18982072-Disease Models, Animal,
pubmed-meshheading:18982072-Disease Progression,
pubmed-meshheading:18982072-Female,
pubmed-meshheading:18982072-Humans,
pubmed-meshheading:18982072-Injections, Intra-Articular,
pubmed-meshheading:18982072-Knee Joint,
pubmed-meshheading:18982072-Male,
pubmed-meshheading:18982072-Membrane Proteins,
pubmed-meshheading:18982072-Mice,
pubmed-meshheading:18982072-Mice, Inbred BALB C,
pubmed-meshheading:18982072-Middle Aged,
pubmed-meshheading:18982072-Peptidoglycan,
pubmed-meshheading:18982072-Synovial Fluid,
pubmed-meshheading:18982072-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis.
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pubmed:affiliation |
Department of Rheumatology and Inflammation Research, Göteborg University, Göteborg, Sweden. mats.dehlin@vgregion.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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