Linked Life Data

18981562

Source:http://linkedlifedata.com/resource/pubmed/id/18981562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-11-4
pubmed:abstractText
Licochalcone A, a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 microM licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G1 to S phase. In addition, 5 microM licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27(kip1) expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0918-6158
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1996-2000
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:18981562-Animals, pubmed-meshheading:18981562-Blotting, Western, pubmed-meshheading:18981562-Cell Cycle, pubmed-meshheading:18981562-Cell Cycle Proteins, pubmed-meshheading:18981562-Cell Proliferation, pubmed-meshheading:18981562-Cell Survival, pubmed-meshheading:18981562-Cells, Cultured, pubmed-meshheading:18981562-Chalcones, pubmed-meshheading:18981562-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:18981562-Flow Cytometry, pubmed-meshheading:18981562-Glycyrrhiza, pubmed-meshheading:18981562-Muscle, Smooth, Vascular, pubmed-meshheading:18981562-Phosphorylation, pubmed-meshheading:18981562-Platelet-Derived Growth Factor, pubmed-meshheading:18981562-Proto-Oncogene Proteins c-akt, pubmed-meshheading:18981562-Rats, pubmed-meshheading:18981562-Rats, Sprague-Dawley
pubmed:year
2008
pubmed:articleTitle
Anti-proliferative effect of licochalcone A on vascular smooth muscle cells.
pubmed:affiliation
Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, NIH, Seoul, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't