18981287

Source:http://linkedlifedata.com/resource/pubmed/id/18981287

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005854, umls-concept:C0017725, umls-concept:C0030054, umls-concept:C0178666, umls-concept:C0871712, umls-concept:C1705810
pubmed:issue	2
pubmed:dateCreated	2009-1-23
pubmed:abstractText	In the current study, we determined the functional significance of sodium-dependent/-independent glucose transporters at the neurovasculature during oxygen glucose deprivation (OGD). Confluent brain endothelial cells cocultured with astrocytes were exposed to varying degrees of in vitro stroke conditions. Glucose transporter (GLUT) 1 and sodium glucose cotransporter (SGLT) activity were investigated by luminal membrane uptake and transport studies using [(3)H]D-glucose and also by [(14)C]alpha-methyl D-glucopyranoside (AMG), a specific, nonmetabolized substrate of SGLT. In vivo middle cerebral artery occlusion experiments were tested to determine whether blood-brain barrier (BBB) SGLT activity was induced during ischemia. Increases in luminal D-glucose and AMG uptake and transport were observed with in vitro stroke conditions. Specific inhibitor experiments suggest a combined role for both SGLT and GLUT1 at the BBB during OGD. A time-dependent increase in the uptake of AMG was also seen in mice exposed to permanent focal ischemia, and this increase was sensitive to the SGLT inhibitor, phlorizin. Infarct and edema ratio during ischemia were significantly decreased by the inhibition of this transporter. These results show that both GLUT1 and SGLT play a role at the BBB in the blood-to-brain transport of glucose during ischemic conditions, and inhibition of SGLT during stroke has the potential to improve stroke outcome. Pharmacological modulation of this novel BBB transporter could prove to be a brain vascular target in stroke.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/NS-O46526, http://linkedlifedata.com/resource/pubmed/grant/R01 NS046526-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 NS046526-02, http://linkedlifedata.com/resource/pubmed/grant/R01 NS046526-03, http://linkedlifedata.com/resource/pubmed/grant/R01 NS046526-04, http://linkedlifedata.com/resource/pubmed/grant/R01 NS046526-05
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0376362
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Glucose, http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transport Proteins..., http://linkedlifedata.com/resource/pubmed/chemical/Sodium
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1521-0103
pubmed:author	pubmed-author:AbbruscatoThomas JTJ, pubmed-author:BhatG JayaramaGJ, pubmed-author:RoderKaren EKE, pubmed-author:ThekkumkaraThomas JTJ, pubmed-author:VemulaSharanyaS, pubmed-author:YangTianzhiT
pubmed:issnType	Electronic
pubmed:volume	328
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	487-95
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:18981287-Animals, pubmed-meshheading:18981287-Anoxia, pubmed-meshheading:18981287-Biological Transport, pubmed-meshheading:18981287-Blood-Brain Barrier, pubmed-meshheading:18981287-Cells, Cultured, pubmed-meshheading:18981287-Endothelial Cells, pubmed-meshheading:18981287-Endothelium, Vascular, pubmed-meshheading:18981287-Glucose, pubmed-meshheading:18981287-Glucose Transport Proteins, Facilitative, pubmed-meshheading:18981287-Mice, pubmed-meshheading:18981287-Sodium
pubmed:year	2009
pubmed:articleTitle	A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation.
pubmed:affiliation	Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79016, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural