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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-1-15
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pubmed:abstractText |
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase LYP, has recently emerged as an important risk factor for human autoimmunity. Here we report that another missense substitution (R263Q) within the catalytic domain of LYP leads to reduced phosphatase activity. High-resolution structural analysis revealed the molecular basis for this loss of function. Furthermore, the Q263 variant conferred protection against human systemic lupus erythematosus, reinforcing the proposal that inhibition of LYP activity could be beneficial in human autoimmunity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-10025920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-15004560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-15208781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-15273934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-16175503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-16273109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-16461343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-16731003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-16760194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-16818372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-17360460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-17387180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-17393452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-17676365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-17878369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-17934143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-18056643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-18093540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-18204447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-18301444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-18425130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-3061754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-314668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-3260404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-6208306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-6821369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-7984417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-9324032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981062-9874568
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2083
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pubmed:author |
pubmed-author:Alarcon-RiquelmeMarta EME,
pubmed-author:AllayeeHoomanH,
pubmed-author:ArnettFrank CFC,
pubmed-author:BottiniNunzioN,
pubmed-author:ChenXiaojiang SXS,
pubmed-author:D'AlfonsoSandraS,
pubmed-author:DasguptaJhimliJ,
pubmed-author:FiorilloEdoardoE,
pubmed-author:Gonzalez-GayMiguel AMA,
pubmed-author:HartialaJaanaJ,
pubmed-author:HeYantaoY,
pubmed-author:Italian Collaborative Group,
pubmed-author:MartinJavierJ,
pubmed-author:OrrúValeriaV,
pubmed-author:Ortego-CentenoNorbertoN,
pubmed-author:Pons-EstelBernardoB,
pubmed-author:RuedaBlancaB,
pubmed-author:StanfordStephanie MSM,
pubmed-author:TsaiSophia JSJ,
pubmed-author:TsaoBetty PBP,
pubmed-author:WuHuiH,
pubmed-author:ZhangZhong-YinZY,
pubmed-author:ZhaoLeiL
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
569-79
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pubmed:dateRevised |
2011-4-22
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pubmed:meshHeading |
pubmed-meshheading:18981062-Amino Acid Sequence,
pubmed-meshheading:18981062-Cell Line,
pubmed-meshheading:18981062-Cohort Studies,
pubmed-meshheading:18981062-European Continental Ancestry Group,
pubmed-meshheading:18981062-Humans,
pubmed-meshheading:18981062-Lupus Erythematosus, Systemic,
pubmed-meshheading:18981062-Models, Molecular,
pubmed-meshheading:18981062-Molecular Sequence Data,
pubmed-meshheading:18981062-Mutation, Missense,
pubmed-meshheading:18981062-Polymorphism, Genetic,
pubmed-meshheading:18981062-Protein Structure, Tertiary,
pubmed-meshheading:18981062-Protein Tyrosine Phosphatase, Non-Receptor Type 22,
pubmed-meshheading:18981062-Risk Factors,
pubmed-meshheading:18981062-Sequence Alignment
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pubmed:year |
2009
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pubmed:articleTitle |
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
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pubmed:affiliation |
Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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