|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0025149,
umls-concept:C0044602,
umls-concept:C0285761,
umls-concept:C0597298,
umls-concept:C0599894,
umls-concept:C0600210,
umls-concept:C1150481,
umls-concept:C1368105,
umls-concept:C1451005,
umls-concept:C1514485,
umls-concept:C1705325
|
|
pubmed:issue |
21
|
|
pubmed:dateCreated |
2008-11-4
|
|
pubmed:abstractText |
The phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in human cancer and plays a crucial role in medulloblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K/Akt signaling as a novel antiproliferative approach in medulloblastoma.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6761-9
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:18980969-Cell Line, Tumor,
pubmed-meshheading:18980969-Cell Movement,
pubmed-meshheading:18980969-Cell Proliferation,
pubmed-meshheading:18980969-Down-Regulation,
pubmed-meshheading:18980969-Drug Delivery Systems,
pubmed-meshheading:18980969-Drug Resistance, Neoplasm,
pubmed-meshheading:18980969-Humans,
pubmed-meshheading:18980969-Isoenzymes,
pubmed-meshheading:18980969-Medulloblastoma,
pubmed-meshheading:18980969-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18980969-RNA Interference,
pubmed-meshheading:18980969-Signal Transduction
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.
|
|
pubmed:affiliation |
Department of Oncology, University Children's Hospital Zurich, Zurich, Switzerland.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
