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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-11-3
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pubmed:abstractText |
Human immunodeficiency virus (HIV) infection frequently causes neurologic disease even with anti-retroviral treatment. Although associations between MHC class I alleles and acquired immunodeficiency syndrome (AIDS) have been reported, the role MHC class I alleles play in restricting development of HIV-induced organ-specific diseases, including neurologic disease, has not been characterized. This study examined the relationship between expression of the MHC class I allele Mane-A*10 and development of lentiviral-induced central nervous system (CNS) disease using a well-characterized simian immunodeficiency (SIV)/pigtailed macaque model. The risk of developing CNS disease (SIV encephalitis) was 2.5 times higher for animals that did not express the MHC class I allele Mane-A*10 (P = 0.002; RR = 2.5). Animals expressing the Mane-A*10 allele had significantly lower amounts of activated macrophages, SIV RNA, and neuronal dysfunction in the CNS than Mane-A*10 negative animals (P<0.001). Mane-A*10 positive animals with the highest CNS viral burdens contained SIV gag escape mutants at the Mane-A*10-restricted KP9 epitope in the CNS whereas wild type KP9 sequences dominated in the brain of Mane-A*10 negative animals with comparable CNS viral burdens. These concordant findings demonstrate that particular MHC class I alleles play major neuroprotective roles in lentiviral-induced CNS disease.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-10559366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-10694578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-11829347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-11899095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-12232830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-12424698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-12525683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-12885919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-12907390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-14581571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-15613296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-15827187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-15855434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-16128923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-16317019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-16511412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-16682496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-17096100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-17180161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-17914061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-18240960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-7486867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-8057491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18978944-9284828
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e3603
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18978944-Alleles,
pubmed-meshheading:18978944-Amyloid beta-Protein Precursor,
pubmed-meshheading:18978944-Animals,
pubmed-meshheading:18978944-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18978944-Central Nervous System Infections,
pubmed-meshheading:18978944-Cohort Studies,
pubmed-meshheading:18978944-Cytoprotection,
pubmed-meshheading:18978944-Genes, MHC Class I,
pubmed-meshheading:18978944-Immunity, Innate,
pubmed-meshheading:18978944-Lentivirus Infections,
pubmed-meshheading:18978944-Macaca nemestrina,
pubmed-meshheading:18978944-Macrophage Activation,
pubmed-meshheading:18978944-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:18978944-Retrospective Studies,
pubmed-meshheading:18978944-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:18978944-Simian immunodeficiency virus,
pubmed-meshheading:18978944-Viral Load
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pubmed:year |
2008
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pubmed:articleTitle |
Natural host genetic resistance to lentiviral CNS disease: a neuroprotective MHC class I allele in SIV-infected macaques.
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pubmed:affiliation |
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. jmankows@jhmi.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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