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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-11-3
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pubmed:databankReference |
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pubmed:abstractText |
We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Gene expression profile analysis of the ALL cells demonstrated significant overlap with human MLL-rearranged ALL. ChIP-chip analysis demonstrated histone H3 lysine 79 (H3K79) methylation profiles that correlated with Mll-AF4-associated gene expression profiles in murine ALLs and in human MLL-rearranged leukemias. Human MLL-rearranged ALLs could be distinguished from other ALLs by their H3K79 profiles, and suppression of the H3K79 methyltransferase DOT1L inhibited expression of critical MLL-AF4 target genes. We thus demonstrate that ectopic H3K79 methylation is a distinguishing feature of murine and human MLL-AF4 ALLs and is important for maintenance of MLL-AF4-driven gene expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-10891426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-11314021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-11417488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-11511376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-11607819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-11731795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-12086872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-12453418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-12453419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-12620411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-12730115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-14701735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-15175259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-15635450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-15851025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-15856011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-15941828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16199517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16551973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16607274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16618801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16636056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16756492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16862118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-16895995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-17135274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-1717054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-17632057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-17891136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-17957188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-18285465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-18371366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-18538732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-18977321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-7477409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-7660125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-8224839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-8481519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18977325-9292512
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/DOT1L protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dot1l protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histone-Lysine N-Methyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HoxA protein,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/MLL-AF4 fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Methyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/histone methyltransferase
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1878-3686
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pubmed:author |
pubmed-author:ArmstrongScott ASA,
pubmed-author:BrackenAdrian PAP,
pubmed-author:FaberJoergJ,
pubmed-author:FengZhaohuiZ,
pubmed-author:JesneckJonathanJ,
pubmed-author:KrivtsovAndrei VAV,
pubmed-author:KungAndrew LAL,
pubmed-author:KutokJeffery LJL,
pubmed-author:LemieuxMadeleine EME,
pubmed-author:SilvermanLewis BLB,
pubmed-author:SinhaAmit UAU,
pubmed-author:SridharVempatiV,
pubmed-author:XiaXiaoboX
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
355-68
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pubmed:dateRevised |
2011-2-8
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pubmed:meshHeading |
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