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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-11-3
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pubmed:abstractText |
We evaluated risk factors and treatment outcomes associated with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) in Germany in 2004-2006. In 177 (4%) of 4,557 culture-positive TB cases, Mycobacterium tuberculosis isolates were identified as MDR TB; an additional 7 (0.15%) met criteria for XDR TB. Of these 184 patients, 148 (80%) were born in countries of the former Soviet Union. In patients with XDR TB, hospitalization was longer (mean +/- SD 202 +/- 130 vs. 123 +/- 81 days; p = 0.015) and resistance to all first-line drugs was more frequent (36% vs. 86%; p = 0.013) than in patients with MDR TB. Seventy-four (40%) of these 184 patients received treatment with linezolid. Treatment success rates ranged from 59% for the entire cohort (59% for MDR TB and 57% for XDR TB) to 87% for those with a definitive outcome (n = 125; 89% for MDR TB and 80% for XDR TB). Extensive drug susceptibility testing and availability of second- and third-line drugs under inpatient management conditions permit relatively high treatment success rates in MDR- and XDR TB.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-11320389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-11550122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-11605880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-11747939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-12099753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-12234129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-12499228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-15541095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-15664227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-15907341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-15911549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-15971391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-16557213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-16622970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-16774814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-16845631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17084757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17096498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17143816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17174706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17201094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17242139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17519090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17552090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17690121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17968823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-17987113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-18044040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-18284844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-18288911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-18378786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18976552-7957845
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1080-6059
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pubmed:author |
pubmed-author:CentisRosellaR,
pubmed-author:EkerBarbaraB,
pubmed-author:German TBNET Group,
pubmed-author:HoffmannHaraldH,
pubmed-author:KirstenDetlefD,
pubmed-author:LangeChristophC,
pubmed-author:MiglioriGiovanni BGB,
pubmed-author:MuetterleinRalfR,
pubmed-author:OrtmannJohannesJ,
pubmed-author:Ruesch-GerdesSabineS,
pubmed-author:SchabergTomT,
pubmed-author:SotgiuGiovanniG
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1700-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18976552-Acetamides,
pubmed-meshheading:18976552-Adult,
pubmed-meshheading:18976552-Antitubercular Agents,
pubmed-meshheading:18976552-Cohort Studies,
pubmed-meshheading:18976552-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:18976552-Emigrants and Immigrants,
pubmed-meshheading:18976552-Extensively Drug-Resistant Tuberculosis,
pubmed-meshheading:18976552-Female,
pubmed-meshheading:18976552-Germany,
pubmed-meshheading:18976552-Humans,
pubmed-meshheading:18976552-Male,
pubmed-meshheading:18976552-Mycobacterium tuberculosis,
pubmed-meshheading:18976552-Oxazolidinones,
pubmed-meshheading:18976552-Retrospective Studies,
pubmed-meshheading:18976552-Risk Factors,
pubmed-meshheading:18976552-Sentinel Surveillance,
pubmed-meshheading:18976552-Treatment Outcome,
pubmed-meshheading:18976552-Tuberculosis, Multidrug-Resistant
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pubmed:year |
2008
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pubmed:articleTitle |
Multidrug- and extensively drug-resistant tuberculosis, Germany.
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pubmed:affiliation |
Research Center Borstel, Borstel, Germany.
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pubmed:publicationType |
Journal Article
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