| pubmed-article:18974698 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C0017973 | lld:lifeskim |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C0008466 | lld:lifeskim |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C0019134 | lld:lifeskim |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C1513400 | lld:lifeskim |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:18974698 | lifeskim:mentions | umls-concept:C0205279 | lld:lifeskim |
| pubmed-article:18974698 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18974698 | pubmed:dateCreated | 2008-10-31 | lld:pubmed |
| pubmed-article:18974698 | pubmed:abstractText | Heparin is a widely used anticoagulant which is usually obtained from porcine mucosal tissue. The structure of heparin is comparable to other naturally occurring glycosaminoglycans such as chondroitin sulfate and dermatan sulfate. The commercially available heparin preparations may contain small amounts of dermatan sulfate as a carry-over impurity. More recently (November 2007 to April 2008), an increased incidence of adverse events and deaths associated with the use of heparin alerted regulatory agencies to investigate the composition of heparin. As a result, oversulfated chondroitin sulfate was found to be the main determinant of the observed adverse reactions. This glycosaminoglycan is not usually found in the mammalian tissues. | lld:pubmed |
| pubmed-article:18974698 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18974698 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18974698 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18974698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18974698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18974698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18974698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18974698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18974698 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18974698 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18974698 | pubmed:issn | 0392-9590 | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:FareedJJ | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:JeskeWW | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:MyersLL | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:ClarkMM | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:HoppensteadtD... | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:IqbalOO | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:WalengaJJ | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:CunananJJ | lld:pubmed |
| pubmed-article:18974698 | pubmed:author | pubmed-author:AdiguzelCC | lld:pubmed |
| pubmed-article:18974698 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18974698 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:18974698 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18974698 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18974698 | pubmed:pagination | 370-6 | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:meshHeading | pubmed-meshheading:18974698... | lld:pubmed |
| pubmed-article:18974698 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18974698 | pubmed:articleTitle | Molecular profiling of heparinase-I resistant glycosaminoglycans in contaminated heparins. Comparative studies with uncontaminated heparin and porcine oversulfated chondroitin sulfate. | lld:pubmed |
| pubmed-article:18974698 | pubmed:affiliation | Department of Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, USA. | lld:pubmed |
| pubmed-article:18974698 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18974698 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18974698 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
