Source:http://linkedlifedata.com/resource/pubmed/id/18973765
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2009-2-4
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| pubmed:abstractText |
Sustained attention is modulated by the neurotransmitter noradrenaline. The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. The principal variant in this gene is a C/T change at position -1021, and the T allele at this locus is hypothesised to result in a slower rate of dopamine to noradrenaline conversion than the C allele. Two hundred participants who were genotyped for the DBH C-1021T marker performed the Sustained Attention to Response Task (SART). DBH genotype was found to significantly predict performance; participants with more copies of the T allele made more errors of commission, indicative of lapses in sustained attention. A significant negative correlation was also observed for all participants between errors of commission and mean reaction time. The decrease in noradrenaline occasioned by the T allele may impair sustained attention by reducing participants' ability to remain alert throughout the task and by increasing their susceptibility to distractors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0028-3932
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
47
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
591-4
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| pubmed:dateRevised |
2009-11-11
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| pubmed:meshHeading |
pubmed-meshheading:18973765-Adolescent,
pubmed-meshheading:18973765-Adult,
pubmed-meshheading:18973765-Alleles,
pubmed-meshheading:18973765-Attention,
pubmed-meshheading:18973765-Dopamine beta-Hydroxylase,
pubmed-meshheading:18973765-Female,
pubmed-meshheading:18973765-Genotype,
pubmed-meshheading:18973765-Humans,
pubmed-meshheading:18973765-Kinetics,
pubmed-meshheading:18973765-Magnetic Resonance Imaging,
pubmed-meshheading:18973765-Male,
pubmed-meshheading:18973765-Neuropsychological Tests,
pubmed-meshheading:18973765-Norepinephrine,
pubmed-meshheading:18973765-Prefrontal Cortex,
pubmed-meshheading:18973765-Psychomotor Performance,
pubmed-meshheading:18973765-Reaction Time,
pubmed-meshheading:18973765-Regression Analysis,
pubmed-meshheading:18973765-Young Adult
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Noradrenergic genotype predicts lapses in sustained attention.
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| pubmed:affiliation |
Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland. cmgreene@tcd.ie
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| pubmed:publicationType |
Journal Article
|