Linked Life Data

18973272

Source:http://linkedlifedata.com/resource/pubmed/id/18973272

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pubmed-article:18973272pubmed:abstractTextEpstein-Barr Virus (EBV)-associated immunoblastic lymphoma occurs in immunocompromised patients such as those with AIDS or transplant recipients after primary EBV infection or reactivation of a preexisting latent EBV infection. In the present study, we evaluated the effect of ritonavir, an HIV protease inhibitor, on EBV-positive lymphoblastoid B cells in vitro and in mice model. We found that it induced cell-cycle arrest at G1-phase and apoptosis through down-regulation of cell-cycle gene cyclin D2 and antiapoptotic gene survivin. Furthermore, ritonavir suppressed transcriptional activation of NF-kappaB in these cells. Ritonavir efficiently prevented growth and infiltration of lymphoma cells in various organs of NOD/SCID/gammacnull mice at the same dose used for treatment of patients with AIDS. Our results indicate that ritonavir targets NF-kappaB activated in tumor cells and shows anti-tumor effects. These data also suggest that this compound may have promise for treatment or prevention of EBV-associated lymphoproliferative diseases that occur in immunocompromised patients.lld:pubmed
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pubmed-article:18973272pubmed:copyrightInfoCopyright (c) 2008 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:18973272pubmed:year2009lld:pubmed
pubmed-article:18973272pubmed:articleTitleAn HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells.lld:pubmed
pubmed-article:18973272pubmed:affiliationDepartment of Molecular Virology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.lld:pubmed
pubmed-article:18973272pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18973272pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed