Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-11-27
pubmed:abstractText
Epstein-Barr Virus (EBV)-associated immunoblastic lymphoma occurs in immunocompromised patients such as those with AIDS or transplant recipients after primary EBV infection or reactivation of a preexisting latent EBV infection. In the present study, we evaluated the effect of ritonavir, an HIV protease inhibitor, on EBV-positive lymphoblastoid B cells in vitro and in mice model. We found that it induced cell-cycle arrest at G1-phase and apoptosis through down-regulation of cell-cycle gene cyclin D2 and antiapoptotic gene survivin. Furthermore, ritonavir suppressed transcriptional activation of NF-kappaB in these cells. Ritonavir efficiently prevented growth and infiltration of lymphoma cells in various organs of NOD/SCID/gammacnull mice at the same dose used for treatment of patients with AIDS. Our results indicate that ritonavir targets NF-kappaB activated in tumor cells and shows anti-tumor effects. These data also suggest that this compound may have promise for treatment or prevention of EBV-associated lymphoproliferative diseases that occur in immunocompromised patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1097-0215
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2008 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
622-9
pubmed:meshHeading
pubmed-meshheading:18973272-Animals, pubmed-meshheading:18973272-Apoptosis, pubmed-meshheading:18973272-Blotting, Western, pubmed-meshheading:18973272-Cell Cycle, pubmed-meshheading:18973272-Cell Movement, pubmed-meshheading:18973272-Cell Proliferation, pubmed-meshheading:18973272-Electrophoretic Mobility Shift Assay, pubmed-meshheading:18973272-Epstein-Barr Virus Infections, pubmed-meshheading:18973272-HIV Protease Inhibitors, pubmed-meshheading:18973272-Herpesvirus 4, Human, pubmed-meshheading:18973272-Humans, pubmed-meshheading:18973272-In Situ Hybridization, Fluorescence, pubmed-meshheading:18973272-Lymphoma, B-Cell, pubmed-meshheading:18973272-Mice, pubmed-meshheading:18973272-NF-kappa B, pubmed-meshheading:18973272-Polymerase Chain Reaction, pubmed-meshheading:18973272-Ritonavir, pubmed-meshheading:18973272-Transcriptional Activation, pubmed-meshheading:18973272-Xenograft Model Antitumor Assays
pubmed:year
2009
pubmed:articleTitle
An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells.
pubmed:affiliation
Department of Molecular Virology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't