Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1991-10-21
pubmed:databankReference
pubmed:abstractText
The stromelysins are members of a family of extracellular matrix metalloproteinases. These enzymes may erode the connective tissue in atherosclerotic plaques, leading to fissuring and acute thrombotic events. Cell-specific stromelysin expression in human atherosclerotic plaques was studied by in situ hybridization and immunocytochemistry. Sections were taken from nine coronary arteries: eight with well-established plaques and one normal. Unambiguous signals were seen in five plaques, two were inconclusive, and the remaining sample was negative, as was the normal coronary artery. Stromelysin mRNA transcripts were localized to isolated individual cells, some of which were smooth muscle, in the plaque cap, intima, and adventitia, but not the media. Expression was also seen in large clusters of macrophages that contained intracellular lipid deposits. The isolated expression of stromelysin by smooth muscle cells may reflect local connective tissue remodeling associated with growth and the formation of the plaque, whereas the more extensive expression associated with macrophages may be of greater pathological significance, contributing to the destabilization of the extracellular matrix and eventual plaque rupture.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-1649600, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-1701851, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-1703045, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-1991237, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2110031, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2132731, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2197998, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2317158, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2383557, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2462278, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2536017, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2548640, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2551572, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2571862, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2731232, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2843568, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-2844164, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3015993, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3028709, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3030290, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3141060, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3527502, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3543052, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3801241, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3885978, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-3894382, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-6273789, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-6284907, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-6326095, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-7000966, http://linkedlifedata.com/resource/pubmed/commentcorrection/1896464-884740
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8154-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization.
pubmed:affiliation
Arterial Diseases Unit, Charing Cross Sunley Research Centre, Hammersmith, London, England.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't