|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0027882,
umls-concept:C0033684,
umls-concept:C0069389,
umls-concept:C0205225,
umls-concept:C0205263,
umls-concept:C0441889,
umls-concept:C0442805,
umls-concept:C1454853,
umls-concept:C1709634,
umls-concept:C1882598,
umls-concept:C1999216
|
|
pubmed:issue |
15
|
|
pubmed:dateCreated |
2008-10-30
|
|
pubmed:abstractText |
Senile plaques and neurofibrillary tangles (NFTs) represent two of the major histopathological hallmarks of Alzheimer's disease (AD). The plaques are primarily composed of aggregated amyloid beta (Abeta) peptides. The processing of amyloid-beta precursor protein (AbetaPP) in okadaic acid (OA)-induced tau phosphorylation primary neurons was studied.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0366-6999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
121
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1439-44
|
|
pubmed:meshHeading |
pubmed-meshheading:18959123-Alzheimer Disease,
pubmed-meshheading:18959123-Amyloid Precursor Protein Secretases,
pubmed-meshheading:18959123-Amyloid beta-Protein Precursor,
pubmed-meshheading:18959123-Animals,
pubmed-meshheading:18959123-Blotting, Western,
pubmed-meshheading:18959123-Cell Survival,
pubmed-meshheading:18959123-Cells, Cultured,
pubmed-meshheading:18959123-Cerebral Cortex,
pubmed-meshheading:18959123-Enzyme Inhibitors,
pubmed-meshheading:18959123-Immunohistochemistry,
pubmed-meshheading:18959123-Okadaic Acid,
pubmed-meshheading:18959123-Peptide Fragments,
pubmed-meshheading:18959123-Rats
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
beta-Secretase inhibitor increases amyloid-beta precursor protein level in rat brain cortical primary neurons induced by okadaic acid.
|
|
pubmed:affiliation |
Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
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|
pubmed:publicationType |
Journal Article
|
