Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-10-29
pubmed:abstractText
Although positron emission tomography (PET) and the aromatic L-amino acid decarboxylase (AADC) tracer 6-[(18)F]fluoro-L-m-tyrosine (FMT) has been used to assess the integrity of the presynaptic dopamine system in the brain, relatively little has been published in terms of brain FMT uptake values especially for normal human subjects. Twelve normal volunteer subjects were scanned using PET and FMT to determine the range of normal striatal uptake values using Patlak graphical analysis. For comparison, seven adult rhesus monkeys were studied and the data analyzed in the same way. A subset of monkeys that were treated with a unilateral intracarotid artery infusion of the dopamine neurotoxin MPTP showed an 87% decrease in striatal FMT uptake. These findings support the use of PET and FMT to image AADC distribution in both normal and diseased brains using Patlak graphical analysis and tissue input functions.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-10078880, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-10993693, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-12368370, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-14664788, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-15325383, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-16337943, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-16682268, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-16781894, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-16829205, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-1874805, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-3487691, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-4055928, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-7651447, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-7979222, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-8014214, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-8063874, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-8363350, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-8472025, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-9098215, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-9098552, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-9199484, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-9295108, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-9345505, http://linkedlifedata.com/resource/pubmed/commentcorrection/18958223-9733979
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1662-5161
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9
pubmed:year
2007
pubmed:articleTitle
PET 6-[F]fluoro-L-m-tyrosine Studies of Dopaminergic Function in Human and Nonhuman Primates.
pubmed:publicationType
Journal Article