Source:http://linkedlifedata.com/resource/pubmed/id/18958193
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2008-10-29
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| pubmed:abstractText |
We examined influence of the beta-amyloid peptide (betaAP) (25-35) neurotoxic fragment on Helix lucorum food-aversion learning. Testing with aversively conditioned carrot showed that 2, 5 and 14 days after training the betaAP-injected group responded in a significantly larger number of cases and with a significantly smaller latency than the sham-injected control group. The results demonstrate that the AP partially impairs the learning process. In an attempt to specify what component of memory is impaired we compared responses in a context in which the snails were aversively trained, and in a neutral context. It was found that the sham-injected learned snails significantly less frequently took the aversively conditioned food in the context in which the snails were shocked, while the betaAP-injected snails remembered the aversive context 2 days after associative training, but were not able to distinguish two contexts 5, and 14 days after training. In a separate series of experiments a specific context was associated with electric shock, and changes in general responsiveness were tested in two contexts several days later. It was found that the betaAP-injected snails significantly increased withdrawal responses in all tested contexts, while the sham-injected control animals selectively increased responsiveness only in the context in which they were reinforced with electric shocks. These results demonstrate that the betaAP (25-35) interferes with the learning process, and may play a significant role in behavioral plasticity and memory by selectively impairing only one component of memory - the context memory.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-10735393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-11193794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-12367592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-12670422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-12927332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-1406936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-15326953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-15353361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-16140161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-1656157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-17596019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-2472918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-3567566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-8321906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-8747164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-8873152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958193-9143266
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
1662-5153
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
2
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3
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| pubmed:year |
2008
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| pubmed:articleTitle |
Impairment of context memory by beta-amyloid peptide in terrestrial snail.
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| pubmed:affiliation |
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences Moscow, Russia.
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| pubmed:publicationType |
Journal Article
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