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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-10-29
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pubmed:abstractText |
It is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular progestin receptors, progesterone's anxiety reducing effects have solely been attributed to its rapid non-genomic effects at the GABA A receptor. This modulation occurs following the bioconversion of progesterone to allopregnanolone. Seemingly paradoxical results from some studies suggested that the function of progesterone to reduce anxiety-like behavior may not be entirely clear; therefore, we hypothesized that progesterone might also act upon progestin receptors to regulate anxiety.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e3606
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18958180-Animals,
pubmed-meshheading:18958180-Anxiety,
pubmed-meshheading:18958180-Behavior, Animal,
pubmed-meshheading:18958180-Darkness,
pubmed-meshheading:18958180-Male,
pubmed-meshheading:18958180-Maze Learning,
pubmed-meshheading:18958180-Mifepristone,
pubmed-meshheading:18958180-Progesterone,
pubmed-meshheading:18958180-Rats,
pubmed-meshheading:18958180-Rats, Sprague-Dawley,
pubmed-meshheading:18958180-Receptors, Progesterone,
pubmed-meshheading:18958180-Testosterone,
pubmed-meshheading:18958180-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Progestin receptor-mediated reduction of anxiety-like behavior in male rats.
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pubmed:affiliation |
Department of Psychology, University of Wisconsin, Madison, Wisconsin, United States of America. cauger@wisc.edu
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