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pubmed:abstractText |
Tuberous sclerosis complex (TSC), a tumor syndrome caused by mutations in TSC1 or TSC2 genes, is characterized by the development of hamartomas. We previously isolated, from an angiomyolipoma of a TSC2 patient, a homogenous population of smooth muscle-like cells (TSC2(-/-) ASM cells) that have a mutation in the TSC2 gene as well as TSC2 loss of heterozygosity (LOH) and consequently, do not produce the TSC2 gene product, tuberin. TSC2(-/-) ASM cell proliferation is EGF-dependent.
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pubmed:affiliation |
Laboratory of Pharmacology , Department of Medicine, Surgery and Dentistry- Polo H. San Paolo, Faculty of Medicine, University of Milan, Milan, Italy. elena.lesma@unimi.it
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