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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2008-10-29
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pubmed:abstractText |
There is an increasing need for quantitative and computationally affordable models for analyzing tissue metabolism and hemodynamics in microvascular networks. In this work, we develop a hybrid model to solve for the time-varying oxygen advection-diffusion equation in the vessels and tissue. To obtain a three-dimensional temporal evolution of tissue oxygen concentration for realistic complex vessel networks, we used a graph-based advection model combined with a finite-element based diffusion model and an implicit time-advancing scheme. We validated this algorithm for both static and dynamic conditions. We also applied it to a complex vascular network obtained from a rodent somatosensory cortex. Qualitative agreement was found with in-vivo experiments.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-10089576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-11295873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-11339327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-11761081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-11959622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-15232110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-15773619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-15804970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-15973353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-16050036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-16061400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-16594161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-17200678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-17265794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-17413855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-17867804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-17956980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-18289880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-18483504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-2855531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-3785405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-4020423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-4398818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-7228771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-8013082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-9347608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18958033-9861040
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1094-4087
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17530-41
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pubmed:dateRevised |
2010-10-5
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pubmed:meshHeading |
pubmed-meshheading:18958033-Animals,
pubmed-meshheading:18958033-Blood Flow Velocity,
pubmed-meshheading:18958033-Blood Pressure,
pubmed-meshheading:18958033-Blood Vessels,
pubmed-meshheading:18958033-Diffusion,
pubmed-meshheading:18958033-Imaging, Three-Dimensional,
pubmed-meshheading:18958033-Oxygen,
pubmed-meshheading:18958033-Partial Pressure,
pubmed-meshheading:18958033-Rats,
pubmed-meshheading:18958033-Rats, Sprague-Dawley,
pubmed-meshheading:18958033-Reproducibility of Results
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pubmed:year |
2008
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pubmed:articleTitle |
Oxygen advection and diffusion in a three- dimensional vascular anatomical network.
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pubmed:affiliation |
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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