| pubmed-article:18957723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18957723 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18957723 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:18957723 | lifeskim:mentions | umls-concept:C0007097 | lld:lifeskim |
| pubmed-article:18957723 | lifeskim:mentions | umls-concept:C1302401 | lld:lifeskim |
| pubmed-article:18957723 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:18957723 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:18957723 | lifeskim:mentions | umls-concept:C2745888 | lld:lifeskim |
| pubmed-article:18957723 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18957723 | pubmed:dateCreated | 2008-10-29 | lld:pubmed |
| pubmed-article:18957723 | pubmed:abstractText | Expression of Human Neutrophil Peptides (HNP) 1-3 was recently found to be associated with development of colorectal cancer. Raised defensin-expression in tumours is believed to stem from increased infiltration of neutrophils into tumour environment. To further specify the role of alpha-defensins in tumourigenesis and progression, HNP1-3 were analyzed in colorectal adenomas and carcinomas of 87 patients and quantified in relation to cancer stage and grading. Using the ProteinChip arrays, HNP1-3 were found upregulated in both colorectal adenomas and carcinomas. By combining the array with Laser capture microscopy we were able to confirm that HNP1-3 are expressed by tumour cells but not by neutrophils or other tumour invading cells. These findings suggest that alpha-defensins are more likely to contribute to tumour growth than they are to mount an effective host anti-tumour response. However, the amount of HNP-expression was not found to be related to tumour stage, grading, and serological tumour markers. | lld:pubmed |
| pubmed-article:18957723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18957723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18957723 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18957723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18957723 | pubmed:issn | 0278-0240 | lld:pubmed |
| pubmed-article:18957723 | pubmed:author | pubmed-author:MothesHenning... | lld:pubmed |
| pubmed-article:18957723 | pubmed:author | pubmed-author:KaufmannRolan... | lld:pubmed |
| pubmed-article:18957723 | pubmed:author | pubmed-author:SettmacherUtz... | lld:pubmed |
| pubmed-article:18957723 | pubmed:author | pubmed-author:ErnstGüntherG | lld:pubmed |
| pubmed-article:18957723 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:18957723 | pubmed:author | pubmed-author:MelleChristia... | lld:pubmed |
| pubmed-article:18957723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18957723 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:18957723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18957723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18957723 | pubmed:pagination | 123-9 | lld:pubmed |
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| pubmed-article:18957723 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18957723 | pubmed:articleTitle | Human Neutrophil Peptides 1-3--early markers in development of colorectal adenomas and carcinomas. | lld:pubmed |
| pubmed-article:18957723 | pubmed:affiliation | Department of General, Visceral and Vascular Surgery, Universitätsklinikum Jena, Jena, Germany. | lld:pubmed |
| pubmed-article:18957723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18957723 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18957723 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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