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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-10-29
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pubmed:abstractText |
Expression of Human Neutrophil Peptides (HNP) 1-3 was recently found to be associated with development of colorectal cancer. Raised defensin-expression in tumours is believed to stem from increased infiltration of neutrophils into tumour environment. To further specify the role of alpha-defensins in tumourigenesis and progression, HNP1-3 were analyzed in colorectal adenomas and carcinomas of 87 patients and quantified in relation to cancer stage and grading. Using the ProteinChip arrays, HNP1-3 were found upregulated in both colorectal adenomas and carcinomas. By combining the array with Laser capture microscopy we were able to confirm that HNP1-3 are expressed by tumour cells but not by neutrophils or other tumour invading cells. These findings suggest that alpha-defensins are more likely to contribute to tumour growth than they are to mount an effective host anti-tumour response. However, the amount of HNP-expression was not found to be related to tumour stage, grading, and serological tumour markers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0278-0240
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-9
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pubmed:meshHeading |
pubmed-meshheading:18957723-Adenocarcinoma,
pubmed-meshheading:18957723-Adenoma,
pubmed-meshheading:18957723-Adult,
pubmed-meshheading:18957723-Aged,
pubmed-meshheading:18957723-Aged, 80 and over,
pubmed-meshheading:18957723-Colon,
pubmed-meshheading:18957723-Colorectal Neoplasms,
pubmed-meshheading:18957723-Disease Progression,
pubmed-meshheading:18957723-Female,
pubmed-meshheading:18957723-Humans,
pubmed-meshheading:18957723-Immunoenzyme Techniques,
pubmed-meshheading:18957723-Male,
pubmed-meshheading:18957723-Middle Aged,
pubmed-meshheading:18957723-Neoplasm Invasiveness,
pubmed-meshheading:18957723-Neutrophils,
pubmed-meshheading:18957723-Prognosis,
pubmed-meshheading:18957723-Tissue Array Analysis,
pubmed-meshheading:18957723-Tumor Markers, Biological,
pubmed-meshheading:18957723-alpha-Defensins
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pubmed:year |
2008
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pubmed:articleTitle |
Human Neutrophil Peptides 1-3--early markers in development of colorectal adenomas and carcinomas.
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pubmed:affiliation |
Department of General, Visceral and Vascular Surgery, Universitätsklinikum Jena, Jena, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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