18957424

Source:http://linkedlifedata.com/resource/pubmed/id/18957424

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012984, umls-concept:C0040578, umls-concept:C0056080, umls-concept:C0233494, umls-concept:C0851285, umls-concept:C1155980, umls-concept:C1267092, umls-concept:C1521761, umls-concept:C1527148, umls-concept:C1879547, umls-concept:C2244412
pubmed:issue	52
pubmed:dateCreated	2008-12-22
pubmed:abstractText	The contractile activation of airway smooth muscle tissues stimulates actin polymerization, and the inhibition of actin polymerization inhibits tension development. Actin-depolymerizing factor (ADF) and cofilin are members of a family of actin-binding proteins that mediate the severing of F-actin when activated by dephosphorylation at serine 3. The role of ADF/cofilin activation in the regulation of actin dynamics and tension development during the contractile activation of smooth muscle was evaluated in intact canine tracheal smooth muscle tissues. Two-dimensional gel electrophoresis revealed that ADF and cofilin exist in similar proportions in the muscle tissues, and that approximately 40% of the total ADF/cofilin in unstimulated tissues is phosphorylated. Phospho-ADF/cofilin decreased concurrently with tension development in response to stimulation with acetylcholine (ACh) or potassium depolarization indicating the activation of ADF/cofilin. Expression of an inactive phospho-cofilin mimetic (cofilin S3E) but not wild type cofilin in the smooth muscle tissues inhibited endogenous ADF/cofilin dephosphorylation and ACh-induced actin polymerization. Expression of cofilin S3E in the tissues depressed tension development in response to ACh, but it did not affect myosin light chain phosphorylation. The ACh-induced dephosphorylation of ADF/cofilin required the Ca2+-dependent activation of calcineurin (PP2B). The results indicate that the activation of ADF/cofilin is regulated by contractile stimulation in tracheal smooth muscle and that cofilin activation is required for actin polymerization and tension development in response to contractile stimulation.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 HL 29289, http://linkedlifedata.com/resource/pubmed/grant/R01 HL029289-23, http://linkedlifedata.com/resource/pubmed/grant/R01 HL074099-06, http://linkedlifedata.com/resource/pubmed/grant/R01 HL074099-07
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985121R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine, http://linkedlifedata.com/resource/pubmed/chemical/Actins, http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Cofilin 1
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0021-9258
pubmed:author	pubmed-author:DuLipingL, pubmed-author:GunstSusan JSJ, pubmed-author:HuangYouliangY, pubmed-author:WuYidiY, pubmed-author:ZhaoRongR
pubmed:issnType	Print
pubmed:day	26
pubmed:volume	283
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	36522-31
pubmed:dateRevised	2010-12-3
pubmed:meshHeading	pubmed-meshheading:18957424-Acetylcholine, pubmed-meshheading:18957424-Actins, pubmed-meshheading:18957424-Animals, pubmed-meshheading:18957424-Calcineurin, pubmed-meshheading:18957424-Calcium, pubmed-meshheading:18957424-Cofilin 1, pubmed-meshheading:18957424-Dogs, pubmed-meshheading:18957424-Electrophoresis, Gel, Two-Dimensional, pubmed-meshheading:18957424-Gene Expression Regulation, pubmed-meshheading:18957424-Models, Biological, pubmed-meshheading:18957424-Muscle, Smooth, pubmed-meshheading:18957424-Muscle Contraction, pubmed-meshheading:18957424-Phosphorylation, pubmed-meshheading:18957424-Plasmids, pubmed-meshheading:18957424-Trachea
pubmed:year	2008
pubmed:articleTitle	Actin depolymerization factor/cofilin activation regulates actin polymerization and tension development in canine tracheal smooth muscle.

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