Linked Life Data

18954858

Source:http://linkedlifedata.com/resource/pubmed/id/18954858

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-10-28
pubmed:abstractText
Beginning in development and extending to adult physiology, a close relationship exists between the thyroid gland and the heart. They migrate together during ontogeny and possess common factors of transcriptions. Among them, Nkx2-5 whose mutations were recently described in patients with congenital hypothyroidism. The genomic impact of triiodothyronine (T3) on cardiac tissue allows the activation of synthesis of proteins belonging to the contractile device. The progress realized in the understanding of the mechanisms of cardiac remodelling strengthens the links between both organs : for example the recent discovery of interactions between some microARNs, activated in case of heart failure and the thyroid hormone receptor. There are numerous parallels between hypothyroidism and heart failure. The low- T3 syndrome are the single most significant predictor of cardiovascular and all-cause mortality in adults with heart disease and the treatment by T3 in these circumstances could allow improvement in cardiac function.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-4266
pubmed:author
pubmed:issnType
Print
pubmed:volume
69 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S37-43
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[What's new in the couple thyroid and heart in 2008?].
pubmed:affiliation
CHU Robert Debré, Service d'endocrinologie, diabète et maladies métaboliques, rue du Général Koenig, 51092 Reims. mfrancois@chu-reims.fr
pubmed:publicationType
Journal Article, English Abstract, Review