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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-11-12
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pubmed:abstractText |
Life at altitude depends on adaptation to ambient hypoxia. In the Andes, susceptibility to chronic mountain sickness (CMS), a clinical condition that occurs to native highlanders or to sea level natives with prolonged residence at high altitude, remains poorly understood. We hypothesized that hypoxia-associated gene expression in children of men with CMS might identify markers that predict the development of CMS in adults. We assessed distinct patterns of gene expression of hypoxia-responsive genes in children of highland Andean men, with and without CMS.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-10721618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-10849648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-11443004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-11443005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-12471159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-12610534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-16517406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-16583294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-17522671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-17555402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-17573246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-17580125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-17706469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-17717153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-17823336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-18339930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-18523639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-334676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-5140341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-7566001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-9465117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-9696153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18954447-9881522
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2431
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18954447-Adaptation, Physiological,
pubmed-meshheading:18954447-Adolescent,
pubmed-meshheading:18954447-Adult,
pubmed-meshheading:18954447-Altitude,
pubmed-meshheading:18954447-Altitude Sickness,
pubmed-meshheading:18954447-Anoxia,
pubmed-meshheading:18954447-Child,
pubmed-meshheading:18954447-Child, Preschool,
pubmed-meshheading:18954447-Chronic Disease,
pubmed-meshheading:18954447-Citric Acid Cycle,
pubmed-meshheading:18954447-Cross-Sectional Studies,
pubmed-meshheading:18954447-Dioxygenases,
pubmed-meshheading:18954447-Energy Metabolism,
pubmed-meshheading:18954447-Gene Expression,
pubmed-meshheading:18954447-Glycolysis,
pubmed-meshheading:18954447-Hematocrit,
pubmed-meshheading:18954447-Hemoglobin A,
pubmed-meshheading:18954447-Humans,
pubmed-meshheading:18954447-Male,
pubmed-meshheading:18954447-Predictive Value of Tests,
pubmed-meshheading:18954447-Protein-Serine-Threonine Kinases,
pubmed-meshheading:18954447-RNA, Messenger,
pubmed-meshheading:18954447-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2008
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pubmed:articleTitle |
Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness.
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pubmed:affiliation |
Departament of Paediatrics, Universidad Nacional Mayor de San Marcos, Universidad Peruana Cayetano Heredia, and Instituto de Salud del Niño, Lima, Peru. lhuicho@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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